Document Detail

Effects of nicorandil on rest and effort angina unresponsive to combination therapy with a calcium antagonist and oral nitrate.
MedLine Citation:
PMID:  2952276     Owner:  NLM     Status:  MEDLINE    
The efficacy of nicorandil, a new anti-anginal agent, was evaluated in 11 patients with rest and effort angina not inhibited by combination therapy with a calcium antagonist and an oral nitrate. Electrocardiographic findings during an attack demonstrated ST depression in seven patients, ST elevation in three, and either elevation or depression in two. Coronary angiography in nine patients revealed significant stenosis (greater than or equal to 75%) in eight. Angina persisted in all 11 patients in spite of treatment with 120 to 360 mg/day of diltiazem or 80 mg/day of nifedipine plus 20 to 160 mg/day of isosorbide dinitrate. Three patients were receiving beta-blocker as well; seven were receiving antiplatelet therapy. During combination therapy, patients had between 3.7 and 25 anginal attacks per week (mean +/- SD, 12.2 +/- 6.9). When nicorandil in a dosage of 20 to 40 mg/day was added to the regimen, the mean number of attacks dropped significantly (P less than 0.01) to 1.4 +/- 1.8 times/week. Two patients did not respond to nicorandil. When placebo was substituted for nicorandil in eight of nine responders, the frequency of attacks increased significantly (P less than 0.05) from 0.6 +/- 0.7 to 6.7 +/- 4.8 times/week. Nicorandil did not affect heart rate or blood pressure. These results suggest that nicorandil inhibits rest and effort angina unresponsive to usual doses of calcium antagonist and oral nitrate.
H Araki; N Hayata; T Matsuguchi; M Nakamura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical therapeutics     Volume:  9     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:  1987  
Date Detail:
Created Date:  1987-05-27     Completed Date:  1987-05-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  174-82     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Angina Pectoris / drug therapy*
Diltiazem / therapeutic use
Drug Resistance
Drug Therapy, Combination
Isosorbide Dinitrate / therapeutic use
Middle Aged
Niacinamide / analogs & derivatives*,  therapeutic use
Nifedipine / therapeutic use
Physical Exertion
Prospective Studies
Vasodilator Agents / therapeutic use*
Reg. No./Substance:
0/Vasodilator Agents; 21829-25-4/Nifedipine; 42399-41-7/Diltiazem; 65141-46-0/Nicorandil; 87-33-2/Isosorbide Dinitrate; 98-92-0/Niacinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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