Document Detail

Effects of nicorandil and other antianginal drugs on myocardial pH in the ischemic dog heart.
MedLine Citation:
PMID:  2447430     Owner:  NLM     Status:  MEDLINE    
The effects of nicorandil and other antianginal drugs on the pH of ischemic myocardium were examined in dogs anesthetized with pentobarbital. The myocardial pH was measured with a micro glass pH electrode placed in the inner layers of the area of myocardium perfused by the left anterior descending coronary artery (LAD). The myocardium (LAD area) was made ischemic by partially occluding the LAD so that only about one-third of the normal blood flow was allowed to perfuse the tissue. The period of LAD occlusion was 90 min. By 30 min, the partial occlusion had produced a decrease in myocardial pH (about 0.5 U) which lasted until the end of occlusion. The acidosis in the myocardium induced by LAD partial occlusion was metabolic acidosis. The experimental drugs were injected intravenously 30 min after the LAD was occluded. Nicorandil (50 micrograms/kg), nitroglycerin (20 micrograms/kg), and diltiazem (100 micrograms/kg) moderately restored the myocardial H+ concentrations induced by LAD occlusion; propranolol (1 mg/kg) and sotalol (5 mg/kg) markedly restored these concentrations. It was concluded that all five experimental drugs improved ischemic myocardium; nicorandil, nitroglycerin, and diltiazem only moderately counteracted the increased myocardial H+ concentrations produced by LAD occlusion, whereas propranolol and sotalol markedly returned myocardial pH close to normal levels.
Y Abiko; K Ichihara; K Sakai
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  10 Suppl 8     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1987  
Date Detail:
Created Date:  1988-02-02     Completed Date:  1988-02-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S85-91     Citation Subset:  IM    
Department of Pharmacology, Asahikawa Medical College, Japan.
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MeSH Terms
Acidosis / metabolism
Coronary Disease / metabolism*
Diltiazem / pharmacology
Hydrogen-Ion Concentration
Myocardium / metabolism
Niacinamide / analogs & derivatives*,  pharmacology
Nitroglycerin / pharmacology
Propranolol / pharmacology
Sotalol / pharmacology
Vasodilator Agents / pharmacology*
Reg. No./Substance:
0/Vasodilator Agents; 3930-20-9/Sotalol; 42399-41-7/Diltiazem; 525-66-6/Propranolol; 55-63-0/Nitroglycerin; 65141-46-0/Nicorandil; 98-92-0/Niacinamide

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