Document Detail


Effects of nicorandil on myocardial function and metabolism in the post-ischaemic reperfused heart with or without inhalation anaesthetics.
MedLine Citation:
PMID:  11903068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Nicorandil, which is an ATP-sensitive K channel opener, has been reported to protect the ischaemic myocardium. However, its interaction with inhalation anaesthetics on the ischaemic myocardium has not been well elucidated. So, we have investigated whether isoflurane or sevoflurane modify the effects of nicorandil on cardiac function and metabolism in the rat heart-lung preparation. METHODS: Animals were allocated to 4 groups as follows: Control group, no drug; Nic group, nicorandil; Nic+Iso group, nicorandil and isoflurane; Nic+Sev group, nicorandil and sevoflurane. Seven minutes after the start of perfusion, nicorandil was administered and 10 min after the start of perfusion, the heart was rendered globally ischaemic for 10 min, and then the heart was reperfused for 10 min. RESULTS: LVdP/dt max in the Nic group was higher than those in the other groups. Right atrial pressure in the Nic+Iso and Nic+Sev groups was significantly higher than in the Control and Nic groups. Myocardial ATP in the Nic group was higher than in the other groups. DHBA levels in the perfusate in the Nic and Nic+Iso groups were lower than those in the Control and Nic+Sev groups, but those in the Nic+Sev group were higher than those in the other groups. CONCLUSIONS: Nicorandil improved post-ischaemic cardiac function and preserved high-energy phosphates. However, these beneficial effects of nicorandil were abolished by the combination with isoflurane or sevoflurane. In addition, sevoflurane increased hydroxyl radical formation in the post-ischaemic reperfused heart.
Authors:
A Furuya; S Kashimoto; T Kumazawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  46     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-03-20     Completed Date:  2002-05-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  24-9     Citation Subset:  IM    
Affiliation:
Department of Anaesthesiology, Yamanashi Medical University, Yamanashi, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism
Anesthetics, Inhalation / pharmacology*
Animals
Gentisates / metabolism
Heart / drug effects
Hemodynamics / drug effects*
Isoflurane / pharmacology*
Male
Methyl Ethers / pharmacology*
Myocardial Reperfusion*
Myocardium / metabolism*
Nicorandil / pharmacology*
Potassium Channels / drug effects,  metabolism
Rats
Rats, Wistar
Vasodilator Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Gentisates; 0/Methyl Ethers; 0/Potassium Channels; 0/Vasodilator Agents; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane; 56-65-5/Adenosine Triphosphate; 65141-46-0/Nicorandil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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