Document Detail

Effects of nicorandil on myocardial function and metabolism in the post-ischaemic reperfused heart with or without inhalation anaesthetics.
MedLine Citation:
PMID:  11903068     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Nicorandil, which is an ATP-sensitive K channel opener, has been reported to protect the ischaemic myocardium. However, its interaction with inhalation anaesthetics on the ischaemic myocardium has not been well elucidated. So, we have investigated whether isoflurane or sevoflurane modify the effects of nicorandil on cardiac function and metabolism in the rat heart-lung preparation. METHODS: Animals were allocated to 4 groups as follows: Control group, no drug; Nic group, nicorandil; Nic+Iso group, nicorandil and isoflurane; Nic+Sev group, nicorandil and sevoflurane. Seven minutes after the start of perfusion, nicorandil was administered and 10 min after the start of perfusion, the heart was rendered globally ischaemic for 10 min, and then the heart was reperfused for 10 min. RESULTS: LVdP/dt max in the Nic group was higher than those in the other groups. Right atrial pressure in the Nic+Iso and Nic+Sev groups was significantly higher than in the Control and Nic groups. Myocardial ATP in the Nic group was higher than in the other groups. DHBA levels in the perfusate in the Nic and Nic+Iso groups were lower than those in the Control and Nic+Sev groups, but those in the Nic+Sev group were higher than those in the other groups. CONCLUSIONS: Nicorandil improved post-ischaemic cardiac function and preserved high-energy phosphates. However, these beneficial effects of nicorandil were abolished by the combination with isoflurane or sevoflurane. In addition, sevoflurane increased hydroxyl radical formation in the post-ischaemic reperfused heart.
A Furuya; S Kashimoto; T Kumazawa
Related Documents :
22886538 - Thiazide and thiazide-like diuretics: an opportunity to reduce blood pressure in patien...
9618408 - Effects of trimetazidine on lipid peroxidation and phosphorus metabolites during cold s...
2008108 - Superior protective effect of low-calcium, magnesium-free potassium cardioplegic soluti...
2102808 - Antioxidant protection against damage during cardiac ischemia and reperfusion: effect o...
5499528 - Comparison of the reflex vasomotor responses to separate and combined stimulation of th...
7546998 - Left ventricular morphology and diastolic function in uraemia: echocardiographic eviden...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  46     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-03-20     Completed Date:  2002-05-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  24-9     Citation Subset:  IM    
Department of Anaesthesiology, Yamanashi Medical University, Yamanashi, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenosine Triphosphate / metabolism
Anesthetics, Inhalation / pharmacology*
Gentisates / metabolism
Heart / drug effects
Hemodynamics / drug effects*
Isoflurane / pharmacology*
Methyl Ethers / pharmacology*
Myocardial Reperfusion*
Myocardium / metabolism*
Nicorandil / pharmacology*
Potassium Channels / drug effects,  metabolism
Rats, Wistar
Vasodilator Agents / pharmacology*
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Gentisates; 0/Methyl Ethers; 0/Potassium Channels; 0/Vasodilator Agents; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane; 56-65-5/Adenosine Triphosphate; 65141-46-0/Nicorandil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effective inhibition of nitric oxide production by aminoguanidine does not reverse hypotension in en...
Next Document:  The influence of anaesthesia and surgery on the circadian rhythm of melatonin.