| Effects of nicorandil on the conductive coronary artery of the dog. | |
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MedLine Citation:
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PMID: 2447415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of nicorandil (2-nicotinamidoethyl nitrate, SG-75) on the conductive coronary artery were studied and compared with the effects of nitroglycerin and nifedipine. In isolated perfused canine heart preparations with a support dog, nicorandil produced a decrease in the resistance of the conductive coronary artery at reduced perfusion pressures, whereas nitroglycerin had similar effects even at normal perfusion pressures. In anesthetized closed-chest dogs, nicorandil and nitroglycerin produced an increase in the diameter of the conductive coronary artery (nicorandil less than nitroglycerin). Nifedipine failed to produce dilatation of the conductive coronary artery in both preparations. In isolated ring preparations of conductive coronary artery, all three compounds produced relaxation of the potassium-induced contracture, but only nicorandil and nitroglycerin reversed the lanthanum-induced contracture. |
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Authors:
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S Imai; M Nakazawa; K Takeda; Y Nakagawa; Y Katano; T Tsukada; H Nabata; T Ushijima |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 10 Suppl 8 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1987 |
Date Detail:
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Created Date: 1988-02-02 Completed Date: 1988-02-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S10-6 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Niigata University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Vessels / drug effects* Dogs Female Lanthanum / antagonists & inhibitors Male Muscle, Smooth, Vascular / drug effects Niacinamide / analogs & derivatives*, pharmacology Nicorandil Nifedipine / pharmacology Nitroglycerin / pharmacology Perfusion Potassium / antagonists & inhibitors Vasoconstriction / drug effects Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 21829-25-4/Nifedipine; 55-63-0/Nitroglycerin; 65141-46-0/Nicorandil; 7439-91-0/Lanthanum; 7440-09-7/Potassium; 98-92-0/Niacinamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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