Document Detail


Effects of nicergoline on the cardiovascular system of dogs and rats.
MedLine Citation:
PMID:  6167799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In pentobarbitalized closed-chest dogs, nicergoline (10--100 microgram/kg, i.v.) reduced blood pressure, heart rate, and splanchnic nerve activity. Intracisternal administration of nicergoline (3 microgram/kg) only reduced splanchnic nerve activity. In open-chest dogs, nicergoline reduced blood pressure, cardiac output, and total peripheral resistance but did not change heart rate. In pithed rats treated with a beta-adrenoceptor-blocking agent, nicergoline reduced the pressor responses to noradrenaline and adrenaline. Nicergoline slightly attenuated the pressor responses of dogs to noradrenaline and tyramine and, in addition, reversed the hypertension induced by adrenaline and dimethylphenylpiperazinium. Nicergoline (100 microgram/kg) increased the tachycardia induced in dogs by stimulation of the right cardiovascular nerve and prevented the inhibitory effect of clonidine on this response. However, nicergoline only partially antagonized the effect of clonidine once it was fully established. Nicergoline did not antagonize the hypotensive and bradycardic effects of clonidine when they were established. Nicergoline did not affect the vagally mediated bradycardia evoked by carotid nerve stimulation in beta-adrenoceptor-blocked dogs. The compound did not change blood pressure in Cl spinal cord transected dogs. In conclusion, nicergoline appears to decrease blood pressure by blocking alpha-adrenoceptors and, at least at some doses, by a central inhibition of the sympathetic tone. Nicergoline appears to be a preferential alpha 1-adrenoceptor-blocking agent.
Authors:
A M Huchet; P Mouillé; J Chelly; B Lucet; M F Doursout; P Lechat; H Schmitt
Related Documents :
7261549 - Effects of clonidine on aortic pressure-diameter and elastic stiffness-stress relations...
2874899 - Absence of functioning alpha-adrenergic receptors in mature canine coronary collaterals.
6167799 - Effects of nicergoline on the cardiovascular system of dogs and rats.
8266889 - A study on the effects of inhibition of prostaglandin biosynthesis with flunixin meglum...
23786429 - Tempol blunts afferent arteriolar remodeling in chronic nitric oxide-deficient hyperten...
23385989 - The effect of pressure and shear on autologous fat grafting.
6378439 - The effect of a non-selective lipophilic beta-blocker on the blood pressure and noradre...
7511729 - Regression of left ventricular hypertrophy by converting enzyme inhibition in 12-15-mon...
3434099 - Prognostic value of consecutive peripheral pressure registration after reconstructive p...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  3     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:    1981 Jul-Aug
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  677-91     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Cardiovascular System / drug effects*
Dogs
Ergolines / pharmacology*
Female
Heart Rate / drug effects
Male
Nicergoline / pharmacology*
Rats
Receptors, Adrenergic, alpha / drug effects
Receptors, Histamine / drug effects
Receptors, Muscarinic / drug effects
Sympathetic Nervous System / drug effects,  physiology
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Ergolines; 0/Receptors, Adrenergic, alpha; 0/Receptors, Histamine; 0/Receptors, Muscarinic; 27848-84-6/Nicergoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of parathyroid hormone and related polypeptides on the heart and coronary circulation of dog...
Next Document:  Effects of concentration and steric configuration of propranolol on AV conduction and ventricular re...