Document Detail

Effects of nicardipine on pulmonary and systemic vascular reactivity to oxygen in patients with pulmonary hypertension secondary to chronic obstructive lung disease.
MedLine Citation:
PMID:  1713987     Owner:  NLM     Status:  MEDLINE    
We compared the acute effects of nicardipine and a placebo on the response of pulmonary and systemic circulation to different inspiratory fractional concentrations of O2 (FiO2) in 10 patients with pulmonary hypertension secondary to chronic obstructive lung disease. After catheterization of the pulmonary and femoral arteries, gas mixtures containing 15, 21, and 30% O2 were randomly administered for 20 min each during infusion of saline and then nicardipine (0.06 mg/kg/min). Plasma nicardipine level was maintained at 30 ng/ml. During nicardipine infusion, cardiac index (CI) was significantly higher (+20%, p less than 0.05) than during placebo infusion, with no change in mean pulmonary artery pressure (MPAP). Pulmonary resistances also decreased significantly (-20%) during nicardipine. No change in arterial or mixed venous O2 contents was noted. Mean arterial pressure (MAP) and systemic resistances decreased significantly with nicardipine. Inhaling a hyperoxic mixture was followed by a significant decrease in arterial pressure during placebo infusion; this was not observed during nicardipine. In contrast with systemic circulation, the response of the pulmonary circulation to different FiO2 levels was unaffected by nicardipine.
A Saadjian; F Philip-Joët; B Hot; M Reynaud-Gaubert; A Durand; S Levy; A Arnaud
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  17     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-09-11     Completed Date:  1991-09-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  731-7     Citation Subset:  IM    
Department of Cardiology, C.H.U. Nord, Marseille, France.
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MeSH Terms
Blood Gas Analysis
Cardiac Output / drug effects
Hemodynamics / drug effects
Hypertension, Pulmonary / blood,  complications,  physiopathology*
Lung Diseases, Obstructive / blood,  etiology,  physiopathology*
Middle Aged
Nicardipine / blood,  pharmacology*
Oxygen / blood,  physiology
Pulmonary Artery / drug effects
Pulmonary Circulation / drug effects
Vasomotor System / drug effects*
Reg. No./Substance:
55985-32-5/Nicardipine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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