Document Detail


Effects of nicardipine on cerebral vascular responses to hypocapnia and blood flow velocity in the middle cerebral artery.
MedLine Citation:
PMID:  1926259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We noninvasively evaluated the effects of nicardipine on cerebral vascular responses to hypocapnia and blood flow velocity in the middle cerebral artery of 10 patients aged 17-60 (mean +/- SD 46.1 +/- 11.8) years. During fentanyl/diazepam/nitrous oxide anesthesia, mean blood flow velocity in the middle cerebral artery was measured and cerebral vascular reactivity to hypocapnia induced by hyperventilation was assessed before and during the administration of nicardipine. Mean blood flow velocity was measured using transcranial Doppler ultrasonography, and the cerebral vascular reactivity was expressed as the percentage change in mean blood flow velocity per unit change in end-tidal PCO2. During the administration of 5.1 +/- 1.3 micrograms/kg/min nicardipine, which caused a 26% reduction in mean arterial blood pressure, mean blood flow velocity increased significantly from 57.2 +/- 19.2 to 64.2 +/- 21.6 cm/sec (p less than 0.01, paired t test), whereas cerebral vascular reactivity showed no significant change (4.0 +/- 1.2% and 4.9 +/- 2.5%, respectively). In conclusion, during fentanyl/diazepam/nitrous oxide anesthesia in patients, cerebral vascular reactivity to hypocapnia was maintained and nicardipine-induced hypotension resulted in increased middle cerebral artery blood flow velocity with maintenance of carbon dioxide reactivity to hypocapnia.
Authors:
M Kawaguchi; H Furuya; K Kurehara; M Yamada
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  22     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-11-14     Completed Date:  1991-11-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1170-2     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, Nara Medical University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anesthesia, Inhalation
Blood Flow Velocity
Blood Pressure / drug effects
Cerebral Arteries / drug effects,  physiology*
Cerebrovascular Circulation / drug effects*
Female
Hemodynamics / drug effects
Humans
Hypocapnia / physiopathology*
Male
Middle Aged
Nicardipine / pharmacology*
Ultrasonography
Chemical
Reg. No./Substance:
55985-32-5/Nicardipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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