| Effects of new multi-site hormone blockers on the fertility of male rats. | |
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MedLine Citation:
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PMID: 1270948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects on the fertility of adult male rats of six new synthetic steroids: I, 3-cyano-5alpha-androst-1-en-17-one; II, the 17beta-acetate form of I; III, 17beta-hydroxy-5beta-cyano-androstan-3-one; IV, 6-methylpregnenolone; V, 17beta-hydroxy-17alpha-ethynyl-5beta-cyano-19-norandrostan-3-one; and VI, 19-norspiroxenone (oestr-4-en-3-one-spiro-17alpha-2'-[tetrahydrofuran]) have been tested. After 6 weeks of treatment with daily doses of 5 mg (I, II, III), 15 mg (IV) or 10 mg (V, VI) only steroid VI blocked the completion of spermatogenesis and reduced the number of foetuses sired in at least five females/male. Steroid VI also diminished seminal vesicular, prostatic, testicular and epididymal weights. It inhibited the testicular enzymes, 3beta-hydroxysteroid dehydrogenase-delta4-5-3-oxosteroid isomerase system, 17alpha-hydroxylase, and C17-20 lyase markedly, but did not affect the adrenal dehydrogenase-isomerase system. It depressed, strikingly, testicular and serum levels of testosterone and 5alpha-dihydrotestosterone and reduced pituitary and serum levels of FSH and LH. Although marked depression of target organ weights also occurred with steroids II, IV and V, and reduction of androgen levels and LH in the circulation with III, IV and V, only VI was a potent blocker of male fertility with the exception of a slight block of the siring of viable foetuses by steroids IV and V. The major difference in site of action of steroid VI from the others was the depression of pituitary and serum levels of FSH along with a marked diminution of testicular content of both testosterone and 5alpha-dihydrotestosterone. 19-Norspiroxenone in the rat is a potent anti-oestrogen without inherent oestrogenicity and is anti-uterotrophic. Thus, VI may affect male fertility by virtue of its potent anti-oestrogenic action in the hypothalamus or testis. |
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Authors:
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A S Goldman; B H Shapiro; A W Root |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of endocrinology Volume: 69 ISSN: 0022-0795 ISO Abbreviation: J. Endocrinol. Publication Date: 1976 Apr |
Date Detail:
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Created Date: 1976-08-02 Completed Date: 1976-08-02 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 11-21 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Androstanes
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pharmacology Animals Contraceptive Agents, Male / pharmacology* Dihydrotestosterone / metabolism Epididymis / drug effects Estrenes / pharmacology Fertility / drug effects* Follicle Stimulating Hormone / blood Furans / pharmacology Hormone Antagonists / pharmacology* Hydroxysteroid Dehydrogenases / antagonists & inhibitors Luteinizing Hormone / blood Male Microsomes / drug effects Mixed Function Oxygenases / antagonists & inhibitors Pituitary Gland / analysis Pregnanes / pharmacology Prostate / drug effects Rats Seminal Vesicles / drug effects Spermatogenesis / drug effects Steroid Isomerases / antagonists & inhibitors Testis / drug effects Testosterone / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Androstanes; 0/Contraceptive Agents, Male; 0/Estrenes; 0/Furans; 0/Hormone Antagonists; 0/Pregnanes; 521-18-6/Dihydrotestosterone; 58-22-0/Testosterone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone; EC 1.-/Mixed Function Oxygenases; EC 1.1.-/Hydroxysteroid Dehydrogenases; EC 5.3.3.-/Steroid Isomerases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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