Document Detail

Effects of neutrophil elastase inhibitor on progression of acute lung injury following esophagectomy.
MedLine Citation:
PMID:  17674097     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to evaluate the effect of sivelestat sodium hydrate, a selective inhibitor of neutrophil elastase in the systemic inflammatory response, pulmonary function, and the postoperative clinical course following esophagectomy. Patients with hypoxia associated with surgical stress in the intensive care unit (ICU) immediately after an esophagectomy were eligible for this study. The degree of hypoxia was calculated according to the ratio of arterial oxygen tension (PaO(2)) to the fractional concentration of inspired oxygen (FiO(2))-PaO(2)/FiO(2). Patients with PaO(2)/FiO(2) < 300 mmHg were enrolled in this study. Seven patients were treated with sivelestat, and 10 were not so treated. The degree of hypoxia, the criteria for systemic inflammatory response syndrome (SIRS), and the postoperative clinical course were compared between the two groups. The postoperative decreases in the PaO(2)/FiO(2) ratio were significantly suppressed in the sivelestat group (p < 0.05, by analysis of variance, or ANOVA). Furthermore, 9 of the 10 control group patients developed SIRS on postoperative day 2, whereas only 2 of 7 of the sivelestat group patients developed SIRS (p < 0.05). The postoperative increases in the heart rate were significantly suppressed in the sivelestat group (p < 0.05, ANOVA). The postoperative decreases in the platelet counts were significantly suppressed in the sivelestat group (p < 0.05, ANOVA). The duration of mechanical ventilation and the length of ICU stay for the sivelestat group were shorter than that for the control group. We demonstrated that the postoperative decreases in the PaO(2)/FiO(2) ratio following esophagectomy were significantly suppressed in the sivelestat-treated group. This clinical study showed that a neutrophil elastase inhibitor may thus be a potentially useful drug for treating acute lung injury following esophagectomy.
Satoshi Ono; Hironori Tsujimoto; Shu-Ichi Hiraki; Risa Takahata; Akifumi Kimura; Manabu Kinoshita; Takashi Ichikura; Hidetaka Mochizuki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of surgery     Volume:  31     ISSN:  0364-2313     ISO Abbreviation:  World J Surg     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-17     Completed Date:  2007-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704052     Medline TA:  World J Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1996-2001     Citation Subset:  IM    
Department of Surgery, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama, Japan.
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MeSH Terms
Anoxia / epidemiology
Disease Progression
Esophageal Neoplasms / surgery
Intensive Care Units
Leukocyte Elastase / antagonists & inhibitors*
Middle Aged
Postoperative Complications / epidemiology
Respiratory Distress Syndrome, Adult / diagnosis,  physiopathology,  prevention & control*
Reg. No./Substance:
EC Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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