Document Detail


Effects of neurotensin on the healing of experimental anastomosis of the colon.
MedLine Citation:
PMID:  11925737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The leakage of colonic anastomoses increases perioperative morbidity significantly. The purpose of the study was to investigate the influence of neurotensin, an intestinal trophic peptide, on the healing of colonic anastomosis. Forty-two Wistar-albino rats were separated into three equal groups: Group 1 (control group)--segmental resection of the left colon and end-to-end anastomosis; Group 2 (dexamethasone group)--resection and anastomosis, plus 0.1 mg/kg/day of dexamethasone; Group 3 (neurotensin group)--same surgical procedure plus 300 micrograms/kg/day of neurotensin. Bursting pressure and tissue hydroxyproline content were determined as parameters of the anastomosis strength and healing on the 3rd and 7th days postoperatively. On the 3rd day, mean bursting pressures were 141.4, 146.7 and 73.1 (p = 0.0001) cm of water in the control group, dexamethasone and neurotensin groups respectively. On the 7th day, bursting pressures were measured as 237.4, 100.6 (p = 0.0001) and 72.7 (p = 10(-6)) cm of water, in the control group, dexamethasone and neurotensin groups respectively. Between the 3rd and 7th days, bursting pressures were increased significantly in the control group (p = 0.0001), decreased in the dexamethasone (p = 0.048), and maintained their lowest values in the neurotensin (p = 0.96) groups. On the 7th day, mean hydroxyproline levels were measured as 9.20, 3.30 (p = 0.007), 2.86 (p = 0.007) micrograms, in the control group, dexamethasone, and neurotensin groups respectively. Between the 3rd and 7th days, tissue hydroxyproline levels were increased significantly in the control group (p = 0.004), decreased in the dexamethasone (p = 0.03), and maintained their lowest values in the neurotensin (p = 0.87) groups. The anastomosis resistance to intraluminal pressure was weak, tissue collagen content was insufficient, and healing was inadequate in the dexamethasone and neurotensin groups in respect to the control group. We concluded that neurotensin impaired the healing, and affected the strength of the colonic anastomosis.
Authors:
G Gürleyik; E Gürleyik; A Yilmazcan; A Ozcan; I Onaran; S Unalmiser
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta chirurgica Belgica     Volume:  102     ISSN:  0001-5458     ISO Abbreviation:  Acta Chir. Belg.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-04-02     Completed Date:  2002-09-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370571     Medline TA:  Acta Chir Belg     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  33-6     Citation Subset:  IM    
Affiliation:
Department of Surgery, Haydarpasa Numune Hospital, Istanbul, Turkey. esg@e-kolay.net
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MeSH Terms
Descriptor/Qualifier:
Anastomosis, Surgical
Animals
Anti-Inflammatory Agents / pharmacology
Collagen / biosynthesis
Colon / surgery*
Dexamethasone / pharmacology
Hydroxyproline / metabolism
Male
Neurotensin / pharmacology*
Rats
Rats, Wistar
Surgical Wound Dehiscence
Wound Healing / drug effects*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 39379-15-2/Neurotensin; 50-02-2/Dexamethasone; 51-35-4/Hydroxyproline; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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