| Effects of neuropeptide Y2 receptor blockade on ventricular arrhythmias in rats with acute myocardial infarction. | |
| | |
MedLine Citation:
|
PMID: 17451678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Excessive sympathetic activity is believed to be the key arrhythmogenic factor both in the setting of acute myocardial infarction and during chronic heart failure. The aim of this study was to evaluate the effect of neuropeptide Y2 blockade on malignant ventricular arrhythmias in rats with acute myocardial infarction. Vagotonic dose-finding study for neuropeptide Y2 receptor antagonist, (S)-N2-[2-[4-[(R,S)-5,11-dihydro-6(6h)-oxodibenz[b,e]azepin-11-yl]-1-piperazinyl]-2-oxoethyl] cylopentyl] acetyl]-N-[2-[1,2-dihydro-3,5 (4H)-dioxo-1,2-diphenyl-3H-1,2,4-triazol-4-yl]ethyl]-argininamid (AR-H05359) was conducted in guinea pigs (n=50) and rats (n=3). Induction of postinfarction arrhythmias was conducted in Sprague-Dawley rats that were randomized into 3 groups. Neuropeptide Y2 antagonist treated rats (n=7), placebo group (n=10) and amiodarone treated rats (n=8). Myocardial infarction was induced by ligation of the left coronary artery. Computerized telemetric ECG tracings were obtained continuously before induction of myocardial infarction and up to 120 min postinfarction. Occurrence of ventricular arrhythmias was analyzed according to a 10-point arrhythmia score. There was no difference in the arrhythmia scores between the neuropeptide Y2 and the saline group. The amiodarone treated animals had lower score compared to the neuropeptide Y2 and the placebo group (p<0.05). The blockade of receptors does not reduce ventricular arrhythmias in the rats with acute myocardial infarction. Further studies are needed to evaluate whether increasing vagal tonus during sympathetic activation may be valuable anti-arrhythmic strategy to prevent sudden death in patients with myocardial infarction and heart failure. |
| | |
Authors:
|
Elmir Omerovic; Truls Råmunddal; Malin Lorentzon; Margareta Nordlander |
Related Documents
:
|
7828308 - Left ventricular performance and remodeling in rabbits after myocardial infarction. eff... 11104868 - Differential expression of three types of nitric oxide synthase in both infarcted and n... 7616388 - Effects of nkh477, a water-soluble forskolin derivative, on cardiac function in rats wi... 14980008 - Antihypertensive and anti-arrhythmic effects of an extract of radix stephaniae tetrandr... 3144298 - Intracardiac thrombosis, phospholipid antibodies, and two-chambered right ventricle. 803168 - Prevention of intraoperative myocardial injury by pretreatment with pharmacological age... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-12 |
Journal Detail:
|
Title: European journal of pharmacology Volume: 565 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2007 Jun |
Date Detail:
|
Created Date: 2007-05-28 Completed Date: 2007-07-26 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 138-43 Citation Subset: IM |
Affiliation:
|
Wallenberg Laboratory at Sahlgrenska Academy, Göteborg University, 413 45, Gothenburg, Sweden. elmir@wlab.gu.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arrhythmias, Cardiac / etiology*, prevention & control Guinea Pigs Male Myocardial Infarction / complications* Rats Rats, Sprague-Dawley Receptors, Neuropeptide Y / antagonists & inhibitors, physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Neuropeptide Y; 0/neuropeptide Y2 receptor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Na+/K+-ATPase alpha isoforms expression in stroke-prone spontaneously hypertensive rat heart ventric...
Next Document: New movements in neurofilament transport, turnover and disease.