Document Detail

Effects of neuropeptide Y on mean circulatory filling pressure in intact and ganglionic-blocked conscious rats.
MedLine Citation:
PMID:  1687814     Owner:  NLM     Status:  MEDLINE    
The dose-response effects of neuropeptide Y (NPY) and the vehicle, 0.9% NaCl, on mean arterial pressure (MAP), heart rate (HR) and mean circulatory filling pressure (MCFP), an index of body venous tone, were examined in conscious, intact and hexamethonium-treated rats. Saline infusions in intact and hexamethonium-treated rats did not significantly affect MAP, HR and MCFP. The i.v. infusion of NPY in intact rats dose dependently increased MAP, decreased HR, but did not alter MCFP. In the presence of hexamethonium, the pressor effect of NPY was enhanced, the lack of MCFP effect remained and the bradycardic effect was markedly attenuated. Our results suggest that NPY has moderate effects on MAP, but negligible effects on body venous tone.
A Abdelrahman; C C Pang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  205     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-07-15     Completed Date:  1992-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  253-7     Citation Subset:  IM    
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Antihypertensive Agents / pharmacology
Autonomic Nerve Block
Blood Circulation / drug effects*
Blood Pressure / drug effects
Ganglia, Sympathetic / drug effects,  physiology
Heart Rate / drug effects
Hexamethonium Compounds / pharmacology
Neuropeptide Y / pharmacology*
Rats, Inbred Strains
Reg. No./Substance:
0/Antihypertensive Agents; 0/Hexamethonium Compounds; 0/Neuropeptide Y; 60-26-4/Hexamethonium

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