Document Detail


Effects of neurochemical lesions of the preoptic area on male sexual behavior in the Japanese quail.
MedLine Citation:
PMID:  8374807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two experiments were carried out during which the noradrenergic neurotoxin, 5-amino-2,4-dihydroxy-alpha-methylphenylethylamine (5-ADMP) was applied to the brain of quail in order to evaluate the role of the noradrenergic system in the control of male copulatory behavior. In the first experiment, the ICV injection of 5-ADMP slightly enhanced the sexual behavior observed in testosterone (T)-treated castrated male quail. This brings additional support to the notion that norepinephrine tonically inhibits male copulatory behavior in quail. In the second experiment, 5-ADMP implanted directly into the preoptic area disrupted the restoration by T of copulatory behavior in castrated quail and, at the same time, produced a brain lesion that partly destroyed the sexually dimorphic medial preoptic nucleus, a previously established site of T action on behavior. These lesions produced by a high (presumably too high) concentration of neurotoxin provided an independent confirmation of effects previously observed after electrolytic lesions. Correlation analyses also confirmed that the medial part of the POM just rostral to the anterior commissure is more closely associated with copulatory behavior and may, therefore, represent a key center for steroid action on this behavior.
Authors:
T Bailhache; C Surlemont; J Balthazart
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research bulletin     Volume:  32     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1993  
Date Detail:
Created Date:  1993-10-15     Completed Date:  1993-10-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  273-83     Citation Subset:  IM    
Affiliation:
Laboratory of General and Comparative Biochemistry, University of Liège, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Aromatase / analysis,  metabolism
Cerebral Ventricles / drug effects,  physiology*
Cloaca / physiology
Copulation
Coturnix / physiology*
Dopamine beta-Hydroxylase / analysis,  metabolism
Immunohistochemistry
Injections, Intraventricular
Male
Movement / drug effects
Neurotoxins / administration & dosage,  toxicity*
Orchiectomy
Phenethylamines / administration & dosage,  toxicity*
Preoptic Area / drug effects,  pathology,  physiology*
Sexual Behavior, Animal / physiology*
Testosterone / pharmacology
Chemical
Reg. No./Substance:
0/Neurotoxins; 0/Phenethylamines; 106868-44-4/5-amino-2,4-dihydroxy-alpha-methylphenylethylamine; 58-22-0/Testosterone; EC 1.14.14.1/Aromatase; EC 1.14.17.1/Dopamine beta-Hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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