Document Detail


Effects of neural refractoriness on spatio-temporal variability in spike initiations with Electrical stimulation.
MedLine Citation:
PMID:  17009486     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this paper, the effects of neural refractoriness on action potential (spike) initiations with electrical stimulation are investigated using computer modeling and simulation techniques. The computational model was composed of a myelinated nerve fiber with 50 nodes of Ranvier, each consisting of stochastic sodium and potassium channels, making it possible to represent the fluctuations of spike initiation. A series of two-pulse stimuli was presented by a stimulating electrode above the central (26th) node of Ranvier. The amplitude of the first (masker) pulse stimulus was set such that the masker pulse stimulus evoked spikes on each trial, while that of the second (probe) pulse stimulus was set such that the probe pulse stimulus evoked spikes on a half of trials, threshold values. Then the transmembrane potentials in response to the probe pulse stimulus were recorded at each node (i.e., 1-50 nodes) in order to determine the spike initiation node and time. From the observation of the spike initiation node and time, a spatio-temporal histogram as well as a spatial variability and a temporal variability of spike initiations was generated which allowed us to interpret fluctuations in spike initiation node and time. It was shown that the distribution of spike initiations tended to become greater spatially and longer temporally as the masker-probe intervals (MPIs) of the two-pulse stimuli shortened. It was also shown that the number of activated sodium channels as functions of space and time tended to become smaller due to inactivation of sodium channels and varied spatially and temporally as MPIs shortened. These findings may imply that the stochastic sodium channels during a relative refractory period may contribute to enhancing the fluctuations in spike initiations, and give us an insight into encoding information with electric stimuli to improve the performance of the prosthetic devices, especially cochlear implants.
Authors:
Hiroyuki Mino; Jay T Rubinstein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society     Volume:  14     ISSN:  1534-4320     ISO Abbreviation:  IEEE Trans Neural Syst Rehabil Eng     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-10-02     Completed Date:  2006-10-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101097023     Medline TA:  IEEE Trans Neural Syst Rehabil Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-80     Citation Subset:  IM    
Affiliation:
Department of Electrical and Computer Engineering, Kanto Gakuin University, Yokohama 236-8501, Japan. mino@ieee.org
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology*
Animals
Cochlear Nerve / physiology*
Computer Simulation
Electric Stimulation / methods*
Humans
Ion Channel Gating / physiology
Models, Neurological*
Models, Statistical
Refractory Period, Electrophysiological / physiology*
Sodium Channels / physiology*
Grant Support
ID/Acronym/Agency:
N01-DC-9-2106/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Sodium Channels

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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