Document Detail

Effects of nephron reduction and dietary protein content on renal ammoniagenesis in the rat.
MedLine Citation:
PMID:  240055     Owner:  NLM     Status:  MEDLINE    
Urinary ammonium excretion, in vitro ammoniagenesis and the activities of renal cortical phosphate-dependent glutaminase (PDG) and glutamic dehydrogenase (GLDH) were measured in rats with a reduced renal mass. Following contralateral nephrectomy, ammonium excretion per nephron, ammonia production and the activities of PDG and GLDH were all increased significantly in remnant kidneys of rats fed high protein diets. In rats fed low protein diets, although PDG activity increased, GLDH activity and ammonia production and excretion did not increase in remnant kidneys following contralateral nephrectomy. Ammonia production and excretion were greater in rats fed high than low protein diets, a difference that was corrected by the addition of mineral acid to the diets of low protein-fed rats. Acid supplementation to the low protein group did not result in enhanced ammonia production or GLDH activity following a reduction in renal mass. The data indicate that the increased rate of ammoniagenesis which occurs following nephron reduction is markedly influenced by dietary protein content. A lack of enhanced GLDH activity may underlie the lack of increased ammonia production of low protein-fed rats following nephron reduction.
A C Schoolwerth; R S Sandler; P M Hoffman; S Klahr
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Kidney international     Volume:  7     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-11-20     Completed Date:  1975-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  397-404     Citation Subset:  IM    
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MeSH Terms
Ammonia / metabolism*
Dietary Proteins*
Glutamate Dehydrogenase / metabolism
Glutamates / metabolism
Glutaminase / metabolism
Glutamine / metabolism
Hydrochloric Acid / pharmacology
Hydrogen-Ion Concentration
Kidney / metabolism*,  surgery*
Kidney Cortex / enzymology,  metabolism
Nephrons / surgery*
Quaternary Ammonium Compounds / urine
Reg. No./Substance:
0/Dietary Proteins; 0/Glutamates; 0/Phosphates; 0/Quaternary Ammonium Compounds; 56-85-9/Glutamine; 7647-01-0/Hydrochloric Acid; 7664-41-7/Ammonia; EC Dehydrogenase; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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