| Effects of neonatal treatment with valproic acid on vasopressin immunoreactivity and olfactory behaviour in mice. | |
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MedLine Citation:
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PMID: 21793947 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Recent findings demonstrate that epigenetic modifications are required for sexual differentiation of the brain. For example, neonatal administration of the histone deacetylase inhibitor, valproic acid, blocks masculinisation of cell number in the principal nucleus of the bed nucleus of the stria terminalis (BNST). Here we examined effects of valproic acid on neurochemistry and behaviour, focusing on traits that are sexually dimorphic and linked to the BNST. Newborn mice were treated with saline or valproic acid and the effect on vasopressin immunoreactivity and olfactory preference behavior examined in adulthood. As expected, males had more vasopressin immunoreactive fibers than females in the lateral septum and medial dorsal thalamus, two projection sites of BNST vasopressin neurons. Neonatal valproic acid increased vasopressin fiber density specifically in females in the lateral septum, thereby reducing the sex difference, and increased vasopressin fibers in both sexes in the medial dorsal thalamus. Effects were not specific to BNST vasopressin projections, however, as valproic acid also significantly increased vasopressin immunoreactivity in the anterior hypothalamic area in both sexes. Subtle sex-specific effects of neonatal valproic acid treatment were observed on olfactory behavior. As predicted, males showed a preference for investigating female-soiled bedding whereas females showed a preference for male-soiled bedding. Valproic acid did not significantly alter olfactory preference, per se, but increased the number of visits females made to female-soiled bedding and the overall time females spent investigating soiled versus clean bedding. Taken together, these results suggest that a transient disruption of histone deacetylation at birth does not have generalized effects on sexual differentiation, but does produce lasting effects on brain neurochemistry and behaviour. |
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Authors:
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Elaine K Murray; Megan M Varnum; Jared L Fernandez; Geert J de Vries; Nancy G Forger |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-27 |
Journal Detail:
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Title: Journal of neuroendocrinology Volume: - ISSN: 1365-2826 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913461 Medline TA: J Neuroendocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Journal of Neuroendocrinology © 2011 Blackwell Publishing. |
Affiliation:
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Neuroscience and Behavior Program, Department of Psychology and Center for Neuroendocrine Studies, University of Massachusetts, Amherst MA, 01003. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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