Document Detail

Effects of nebivolol on liver fibrosis induced by bile duct ligation in wistar rats.
MedLine Citation:
PMID:  23988899     Owner:  NLM     Status:  In-Data-Review    
MATERIALS AND METHODS: After BDL, Wistar rats were divided into three groups (n=24): SO, sham-operated animals; BDL, BDL rats without treatment; BDL+N, BDL rats treated with nebivolol for five weeks. Alanine aminotransferase, aspartate aminotransferase, gamma glutamyltransferase, total bilirubin and albumin levels were assessed. Liver samples collected were stained with hematoxylin-eosin, Masson's trichrom and reticulin.
RESULTS: Mortality reached 37.5% in the BDL group, whereas no deaths were observed in the SO and BDL+N groups. The BDL group showed hepatic damage as evidenced by elevation in serum biochemical parameters and fibrosis scores. These pathophysiological changes were attenuated in the BDL+N group. However, there was no significant difference between these two groups.
CONCLUSION: Nebivolol improved the survival rate of animals with BDL, but was unable to significantly improve liver function or reduce liver fibrosis.
Catarina Teixeira; Elisabete Franco; Paula Alexandra Oliveira; Bruno Colaço; Adelina Gama; João Carrola; Carlos André Pires; Aura Colaço; Maria João Pires
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  27     ISSN:  1791-7549     ISO Abbreviation:  In Vivo     Publication Date:    2013 Sep-Oct
Date Detail:
Created Date:  2013-08-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  635-40     Citation Subset:  IM    
Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, 5000-911 Vila Real, Portugal.
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