| Effects of natural tachykinins on ovine lower urinary tract smooth muscle. | |
| | |
MedLine Citation:
|
PMID: 11679016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. Numerous studies have demonstrated that the urinary bladder is particularly sensitive to tachykinins; rat, rabbit and guinea pig bladders, besides human detrusor, have been the most extensively studied, whereas very little is known about most large animal detrusors. The aim of this work was to study natural tachykinin activity on the lower urinary tract of ovine to make a comparison with data obtained in laboratory animals. 2. As in other animal species, tachykinins are also able to contract ovine bladder smooth muscle. 3. The results reported in this study indicate that in ovine bladder, neurokinin 2 (NK2) receptors are expressed most. In fact, on lamb and sheep bladder neurokinin A (NKA), a NK2- almost selective peptide, was shown to be > 100% more active than the natural tachykinins kassinin (KASS) and eledoisin (ELED). Eledoisin was shown to be 50% less active than KASS, which is typical behaviour for an almost exclusively NK2 receptor population. Moreover, NK1- preferential peptides, namely substance P (SP) and physalaemin (PHYS), showed a lack of activity even when applied at high concentrations. 4. The results reported in this study show that lamb and sheep detrusor represent a good alternative model for the characterization of NK2-selective tachykinins. |
| | |
Authors:
|
P Tucci; P Bolle; C Severini |
Related Documents
:
|
9175156 - Tachykinins in the gut. part ii. roles in neural excitation, secretion and inflammation. 1718986 - Amyloid-beta peptide, substance p, and bombesin bind to the serpin-enzyme complex recep... 17371796 - A novel, conformation-specific allosteric inhibitor of the tachykinin nk2 receptor (nk2... 14632686 - Cgrp1 and nk1 receptors in postnatal, developing rat dental tissues. 1440606 - Modulation of m1 and m2 muscarinic receptor subtypes following repeated organophosphate... 21832286 - Role of the transmembrane domain 4/extracellular loop 2 junction of the human gonadotro... |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: Journal of autonomic pharmacology Volume: 21 ISSN: 0144-1795 ISO Abbreviation: J Auton Pharmacol Publication Date: 2001 Apr |
Date Detail:
|
Created Date: 2001-11-06 Completed Date: 2002-01-15 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8106455 Medline TA: J Auton Pharmacol Country: England |
Other Details:
|
Languages: eng Pagination: 79-84 Citation Subset: IM |
Affiliation:
|
Dipartimento di Farmacologia delle Sostanze Naturali e Fisiologia Generale, University of Rome 'La Sapienza', Ple Aldo Moro 5, 00185 Rome, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Eledoisin / pharmacology Female Guinea Pigs Kassinin / pharmacology Male Muscle, Smooth / drug effects* Neurokinin A / pharmacology Peptides, Cyclic / pharmacology Receptors, Neurokinin-2 / drug effects Sheep Substance P / pharmacology Tachykinins / metabolism* Urinary Tract / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Peptides, Cyclic; 0/Receptors, Neurokinin-2; 0/Tachykinins; 157351-81-0/MEN 10627; 33507-63-0/Substance P; 63968-82-1/Kassinin; 69-25-0/Eledoisin; 86933-74-6/Neurokinin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Spontaneous baroreflex sensitivity as a dynamic measure of cardiac anticholinergic drug effect.
Next Document: Effects of P5, a novel oxazolo(3,2-a)pyridine derivative with a long-acting antihypertensive activit...