| Effects of natural point mutation of rat aquaporin 5 expressed in vitro on its capacity of water permeability and membrane trafficking. | |
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MedLine Citation:
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PMID: 20224238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the colony of Sprague-Dawley (SD) strain, we found that there were rats expressing a mutant AQP5, which has a point mutation at nt 308 (G308A), leading to a replacement of (103)Gly with (103)Asp in the 3rd transmembrane domain. The mutant molecule scarcely expressed in the acinar cells, probably because of ineffective trafficking. The mutant molecule, however, showed normal water permeability when assessed by the oocyte system. |
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Authors:
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Mileva R Karabasil; Kwartarini Murdiastuti; Nunuk Purwanti; Ahmad Azlina; Purevjav Javkhlan; Takahiro Hasegawa; Chenjuan Yao; Tetsuya Akamatsu; Kazuo Hosoi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The journal of medical investigation : JMI Volume: 56 Suppl ISSN: 1349-6867 ISO Abbreviation: J. Med. Invest. Publication Date: 2009 |
Date Detail:
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Created Date: 2010-03-12 Completed Date: 2010-06-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9716841 Medline TA: J Med Invest Country: Japan |
Other Details:
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Languages: eng Pagination: 398-400 Citation Subset: IM |
Affiliation:
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Department of Molecular Oral Physiology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Aquaporin 5 / analysis, genetics*, physiology* Biological Transport / physiology Cell Membrane Permeability / physiology* Female Models, Animal Molecular Sequence Data Oocytes / cytology, metabolism Point Mutation / genetics* Rats Rats, Sprague-Dawley Submandibular Gland / metabolism Water / metabolism* Xenopus laevis |
| Chemical | |
Reg. No./Substance:
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0/Aqp5 protein, rat; 0/Aquaporin 5; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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