| Effects of natural oestrogen therapy on blood pressure and renin-angiotensin system in normotensive and hypertensive menopausal women. | |
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MedLine Citation:
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PMID: 6442719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The blood pressure level and the renin-angiotensin system were investigated in 24 menopausal women (12 normotensive and 12 hypertensive) before, during and after six months of treatment with either oestradiol or trisekvens (sequential preparation containing oestradiol, oestriol and norethisterone acetate). In the normotensive women no significant alterations in systolic or diastolic blood pressure were found during treatment for six months. In the hypertensive women systolic blood pressure fell significantly during treatment with oestradiol as well as with trisekvens, while diastolic pressure did not change. All individual variations of blood pressure were small. The plasma concentrations of renin, angiotensin II and aldosterone remained unchanged during the treatments. A statistically significant increase in plasma renin substrate concentration was observed in all groups with the exception of the normotensive women treated with oestradiol. Menopausal symptoms in hypertensive women may safely be treated with natural oestrogens on the same indications as used for normotensive women. |
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Authors:
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C M Jespersen; K Arnung; C Hagen; T Hilden; F Nielsen; M D Nielsen; J Giese |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of hypertension Volume: 1 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 1983 Dec |
Date Detail:
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Created Date: 1985-06-06 Completed Date: 1985-06-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 361-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angiotensinogen / blood Blood Pressure / drug effects* Climacteric / drug effects* Drug Combinations / therapeutic use Estradiol / therapeutic use Estriol / therapeutic use Estrogens / therapeutic use* Follicle Stimulating Hormone / blood Humans Hypertension / blood, physiopathology* Male Middle Aged Norethindrone / analogs & derivatives, therapeutic use Renin-Angiotensin System / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Estrogens; 11002-13-4/Angiotensinogen; 50-27-1/Estriol; 50-28-2/Estradiol; 66100-41-2/Trisequens; 68-22-4/Norethindrone; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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