Document Detail

Effects of nasal continuous positive airway pressure on pulmonary haemodynamics and tissue oxygenation in patients with obstructive sleep apnoea.
MedLine Citation:
PMID:  10339735     Owner:  NLM     Status:  MEDLINE    
We investigated the acute effects of nasal continuous positive airway pressure (CPAP) on pulmonary haemodynamics and tissue oxygenation in eight men with obstructive sleep apnoea (OSA) by means of right heart catheterization. They were tested at four dosage levels of nasal CPAP: 0, 5, 10, and 15 cmH2O. Nasal CPAP significantly reduced the cardiac index at the 10 and 15 cmH2O doses. The mean pulmonary artery pressure was significantly elevated with 10 and 15 cmH2O, and pulmonary capillary wedge pressure was significantly increased with 15 cmH2O of nasal CPAP. Pulmonary vascular resistance was significantly increased with 10 cmH2O of nasal CPAP. The 5 cmH2O dose of nasal CPAP did not affect significantly these parameters. Mixed venous oxygen tension was unchanged at any pressure. We conclude that tissue oxygenation was maintained in the OSA patients during administration of nasal CPAP, even though a high CPAP clearly affected pulmonary haemodynamics.
T Akashiba; H Minemura; H Yamamoto; D Itoh; N Kosaka; O Saitoh; T Horie
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  4     ISSN:  1323-7799     ISO Abbreviation:  Respirology     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-06-29     Completed Date:  1999-06-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  83-7     Citation Subset:  IM    
First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
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MeSH Terms
Analysis of Variance
Heart Catheterization
Middle Aged
Positive-Pressure Respiration*
Pulmonary Circulation / physiology*
Pulmonary Gas Exchange / physiology*
Sleep Apnea Syndromes / therapy*

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