| Effects of nanosized titanium dioxide on innate immune system of fathead minnow (Pimephales promelas Rafinesque, 1820). | |
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MedLine Citation:
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PMID: 21035856 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Effects of nanosized (<100nm) titanium dioxide (TiO(2)) particles on fish neutrophils and immune gene expression was investigated using the fathead minnow (Pimpehales promelas). Expanded use of TiO(2) in the cosmetic industry has increased the potential exposure risk to aquatic ecosystems and human health. Effects of nano-TiO(2) on neutrophil function of the fathead minnow was investigated using oxidative burst, neutrophil extracellular traps (NETs) release and degranulation of primary granules. The innate immune gene expression was determined with quantitative PCR (qPCR). Application of 0.1μgmL(-1) of nano-TiO(2)in vitro stimulated oxidative burst and NET release. Intraperitoneal injection of 10μgg(-1) of nano-TiO(2) caused a significant decrease in oxidative burst, NETs release and degranulation (21%; 11%; and 30%, decrease, respectively). Fish exposed to nano-TiO(2) for 48h in vivo had significantly increased expression of interleukin 11, macrophage stimulating factor 1, and neutrophil cytosolic factor 2 (4; 2.5; and 2 fold increase, respectively). Nano-TiO(2) has potential to interfere with the evolutionary conserved innate immune system responses, as evidenced with observed changes in gene expression and neutrophil function. This finding encourages the use of fish models in the studies of nanoparticle immunotoxicity. The lowest significant response concentration studied in vitro is four times greater than the estimated environmental concentration for TiO(2) (0.025μgmL(-1)) causing concern about potential impact of nano-TiO(2) on aquatic animals and ecosystems. |
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Authors:
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Boris Jovanović; Lora Anastasova; Eric W Rowe; Yanjie Zhang; Aaron R Clapp; Dušan Palić |
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Publication Detail:
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Type: Journal Article Date: 2010-10-29 |
Journal Detail:
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Title: Ecotoxicology and environmental safety Volume: 74 ISSN: 1090-2414 ISO Abbreviation: Ecotoxicol. Environ. Saf. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805381 Medline TA: Ecotoxicol Environ Saf Country: United States |
Other Details:
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Languages: eng Pagination: 675-83 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Biomedical Sciences, The College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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