| Effects of naltrexone during the descending limb of the blood alcohol curve. | |
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MedLine Citation:
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PMID: 18612879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The neuropharmacological effects of alcohol are known to vary by limb of the blood alcohol curve, yet human laboratory studies of alcoholism pharmacotherapies have largely failed to consider limb of intoxication when examining medication effects on subjective responses to alcohol. This study examined the effects of naltrexone compared to placebo on subjective responses to alcohol at the descending limb of the blood alcohol curve following a controlled intravenous (IV) alcohol administration. Non-treatment-seeking hazardous drinkers (n = 38) completed two double-blind counterbalanced IV alcohol challenge sessions, one after taking naltrexone (50 mg) for three days and one after taking a placebo for three days. During each session, participants reported on subjective responses to alcohol during the descending limb of the blood alcohol curve. Analyses revealed significant main effects of naltrexone, reflecting significantly decreased alcohol-induced stimulation, craving, vigor, positive mood, and alcohol "high" and increased tension as compared to placebo. These findings suggest that naltrexone may exert some of its therapeutic effects via alterations to experiential aspects of intoxication during the descending limb of alcohol intoxication. Additionally, these results highlight the potential utility of considering limb of blood alcohol curve when examining the mechanisms of action of pharmacotherapies thought to alter subjective responses to alcohol. |
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Authors:
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Lara A Ray; Kent E Hutchison; James MacKillop; Robert Miranda; Amy Audette; Robert Swift; Peter M Monti |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions Volume: 17 ISSN: 1521-0391 ISO Abbreviation: Am J Addict Publication Date: 2008 Jul-Aug |
Date Detail:
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Created Date: 2008-07-09 Completed Date: 2008-09-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9208821 Medline TA: Am J Addict Country: United States |
Other Details:
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Languages: eng Pagination: 257-64 Citation Subset: IM |
Affiliation:
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Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA. Lara Ray@brown.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Affect / physiology Alcoholic Intoxication / blood Alcoholism / blood*, psychology Arousal / drug effects, physiology Double-Blind Method Ethanol / administration & dosage, pharmacokinetics* Female Humans Infusions, Intravenous Male Motivation Naltrexone / pharmacology* Narcotic Antagonists / pharmacology* Questionnaires Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
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AA012238/AA/NIAAA NIH HHS; AA14847/AA/NIAAA NIH HHS; M01-RR00051/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Narcotic Antagonists; 16590-41-3/Naltrexone; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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