Document Detail

Effects of naloxone on systemic and regional hemodynamic responses to exercise in dogs.
MedLine Citation:
PMID:  2837452     Owner:  NLM     Status:  MEDLINE    
To determine whether endogenous opiates have a role in circulatory regulation during mild to moderate exercise, 11 chronically instrumented dogs were exercised on a treadmill up a 6% incline at 2.5 and 5.0 mph, each for 20 min, after treatment with either the opiate receptor antagonist naloxone (1 mg/kg bolus and 20 infusion) or normal saline. Naloxone increased plasma beta-endorphin and adrenocorticotropic hormone at rest but had no effect on resting heart rate, aortic pressure, cardiac output, left ventricular time derivative of pressure (dP/dt) and ratio of dP/dt at a developed pressure of 50 mmHg and the developed pressure (dP/dt/P), or plasma catecholamines. Plasma beta-endorphin and adrenocorticotropic hormone increased during exercise. In addition, graded treadmill exercise produced proportional increases in heart rate, cardiac output, aortic pressure, left ventricular dP/dt and dP/dt/P, and blood flow to exercising muscles, right and left ventricular myocardium, and adrenal glands. However, there were no differences in the circulatory responses to exercise between animals receiving naloxone and normal saline. Thus the endogenous opiate system probably does not play an important role in regulating the systemic hemodynamic and blood flow responses to mild and moderate exercise.
N Imai; C K Stone; P D Woolf; C S Liang
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  64     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-07-15     Completed Date:  1988-07-15     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1493-9     Citation Subset:  IM; S    
Department of Medicine, University of Rochester Medical Center, New York 14642.
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MeSH Terms
Adrenocorticotropic Hormone / blood
Blood Pressure / drug effects
Carbon Dioxide / blood
Cardiac Output / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Naloxone / pharmacology*
Oxygen / blood
Partial Pressure
Physical Exertion*
Regional Blood Flow / drug effects
Vascular Resistance / drug effects
beta-Endorphin / blood
Grant Support
Reg. No./Substance:
124-38-9/Carbon Dioxide; 465-65-6/Naloxone; 60617-12-1/beta-Endorphin; 7782-44-7/Oxygen; 9002-60-2/Adrenocorticotropic Hormone

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