| Effects of naloxone on systemic and regional hemodynamic responses to exercise in dogs. | |
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MedLine Citation:
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PMID: 2837452 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine whether endogenous opiates have a role in circulatory regulation during mild to moderate exercise, 11 chronically instrumented dogs were exercised on a treadmill up a 6% incline at 2.5 and 5.0 mph, each for 20 min, after treatment with either the opiate receptor antagonist naloxone (1 mg/kg bolus and 20 micrograms.kg-1.min-1 infusion) or normal saline. Naloxone increased plasma beta-endorphin and adrenocorticotropic hormone at rest but had no effect on resting heart rate, aortic pressure, cardiac output, left ventricular time derivative of pressure (dP/dt) and ratio of dP/dt at a developed pressure of 50 mmHg and the developed pressure (dP/dt/P), or plasma catecholamines. Plasma beta-endorphin and adrenocorticotropic hormone increased during exercise. In addition, graded treadmill exercise produced proportional increases in heart rate, cardiac output, aortic pressure, left ventricular dP/dt and dP/dt/P, and blood flow to exercising muscles, right and left ventricular myocardium, and adrenal glands. However, there were no differences in the circulatory responses to exercise between animals receiving naloxone and normal saline. Thus the endogenous opiate system probably does not play an important role in regulating the systemic hemodynamic and blood flow responses to mild and moderate exercise. |
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Authors:
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N Imai; C K Stone; P D Woolf; C S Liang |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 64 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1988 Apr |
Date Detail:
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Created Date: 1988-07-15 Completed Date: 1988-07-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1493-9 Citation Subset: IM; S |
Affiliation:
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Department of Medicine, University of Rochester Medical Center, New York 14642. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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blood Animals Blood Pressure / drug effects Carbon Dioxide / blood Cardiac Output / drug effects Dogs Heart Rate / drug effects Hemodynamics / drug effects* Male Naloxone / pharmacology* Oxygen / blood Partial Pressure Physical Exertion* Regional Blood Flow / drug effects Vascular Resistance / drug effects beta-Endorphin / blood |
| Grant Support | |
ID/Acronym/Agency:
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HL-30142/HL/NHLBI NIH HHS; HL-30194/HL/NHLBI NIH HHS; HL-30278/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 465-65-6/Naloxone; 60617-12-1/beta-Endorphin; 7782-44-7/Oxygen; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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