| Effects of naloxone on the mechanical activity of isolated rat hearts perfused with morphine or opioid peptides. | |
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MedLine Citation:
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PMID: 3628085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In isolated rat hearts, the infusion for 10 min of 10(-10), 10(-8) or 10(-6) M (-)naloxone affected the cardiac function by markedly increasing the coronary pressure and by reducing both the heart rate and the developed tension. A lower dose of (-)naloxone (10(-11) M) or a dose of 10(-6) M (+)naloxone, did not modify the cardiac function. Morphine (10(-6) or 10(-5) M) and 10(-10), 10(-8) or 10(-6) M methionine-enkephalin or leucine-enkephalin, both significantly reduced the coronary pressure of the isolated rat hearts, during the first 4-6 min of perfusion, but the coronary pressure progressively increased above the control value in the last 4 min of perfusion. Each opioid also influenced the mechanical activity of the isolated rat heart, by significantly lowering both the heart rate and the developed tension. (-)Naloxone, at all the doses tested, was only able to antagonise the hypotensive effect induced by the opioids on the coronary pressure and was ineffective in counteracting the negative inotropic and chronotropic effects produced by each opioid. The perfusion in the presence of (+)naloxone (even at a dose of 10(-6) M) did not affect the opioid-induced changes on both the coronary pressure and the mechanical performance of the isolated heart. |
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Authors:
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C Ventura; C Muscari; S Spampinato; P Bernardi; C M Caldarera |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Peptides Volume: 8 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 1987 Jul-Aug |
Date Detail:
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Created Date: 1987-10-21 Completed Date: 1987-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 695-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Enkephalin, Leucine / pharmacology* Enkephalin, Methionine / pharmacology* Heart / drug effects, physiology* Heart Rate / drug effects Male Morphine / pharmacology* Naloxone / pharmacology* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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465-65-6/Naloxone; 57-27-2/Morphine; 58569-55-4/Enkephalin, Methionine; 58822-25-6/Enkephalin, Leucine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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