Document Detail


Effects of n-3 polyunsaturated fatty acids and of rosuvastatin on left ventricular function in chronic heart failure: a substudy of GISSI-HF trial.
MedLine Citation:
PMID:  20952767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: The GISSI-HF trial showed that n-3 polyunsaturated fatty acids (PUFA), but not rosuvastatin, reduce morbidity and mortality in patients with symptomatic heart failure (HF) of any cause. The aim of this echocardiographic substudy of GISSI-HF was to investigate the effects of n-3 PUFA and of rosuvastatin on left ventricular (LV) function in such patients.
METHODS AND RESULTS: Six hundred and eight chronic HF patients were randomized to n-3 PUFA (n=312) or placebo (n=296); a second randomization was performed to rosuvastatin (n=212) or placebo (n=207). Echocardiographic examinations were recorded at baseline and at 1, 2, and 3 years; offline analysis was performed by a core laboratory to ensure consistent quantitative analysis. Baseline LV ejection fraction (EF) was 30% (95%CI 29-31). Left ventricular ejection fraction increased with n-3 PUFA by 8.1% at 1 year, 11.1% at 2 years, and 11.5% at 3 years vs. 6.3% at 1 year, 8.2% at 2 years, and 9.9% at 3 years in the placebo group (P=0.0050). No other echocardiographic parameter changed significantly. Rosuvastatin effects were not statistically significant.
CONCLUSION: n-3 PUFA can provide a small but statistically significant advantage in terms of LV function in patients with symptomatic HF of any aetiology, already treated with recommended therapies.
Authors:
Stefano Ghio; Laura Scelsi; Roberto Latini; Serge Masson; Ermanno Eleuteri; Michela Palvarini; Olga Vriz; Michele Pasotti; Marco Gorini; Roberto Marchioli; Aldo Maggioni; Luigi Tavazzi;
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-10-16
Journal Detail:
Title:  European journal of heart failure     Volume:  12     ISSN:  1879-0844     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-06-02     Revised Date:  2011-09-29    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1345-53     Citation Subset:  IM    
Affiliation:
Divisione di Cardiologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. s.ghio@smatteo.pv.it
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MeSH Terms
Descriptor/Qualifier:
Aged
Analysis of Variance
Fatty Acids, Omega-3 / pharmacology,  therapeutic use*
Female
Fluorobenzenes / pharmacology,  therapeutic use*
Health Status Indicators
Heart Failure / drug therapy*,  pathology,  ultrasonography
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology,  therapeutic use*
Male
Prognosis
Pyrimidines / pharmacology,  therapeutic use*
Stroke Volume / drug effects
Sulfonamides / pharmacology,  therapeutic use*
Treatment Outcome
Ventricular Function, Left / drug effects*
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fluorobenzenes; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrimidines; 0/Sulfonamides; 287714-41-4/rosuvastatin
Comments/Corrections
Erratum In:
Eur J Heart Fail. 2011 Sep;13(9):1042

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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