| Effects of n-3 polyunsaturated fatty acids and of rosuvastatin on left ventricular function in chronic heart failure: a substudy of GISSI-HF trial. | |
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MedLine Citation:
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PMID: 20952767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The GISSI-HF trial showed that n-3 polyunsaturated fatty acids (PUFA), but not rosuvastatin, reduce morbidity and mortality in patients with symptomatic heart failure (HF) of any cause. The aim of this echocardiographic substudy of GISSI-HF was to investigate the effects of n-3 PUFA and of rosuvastatin on left ventricular (LV) function in such patients. METHODS AND RESULTS: Six hundred and eight chronic HF patients were randomized to n-3 PUFA (n=312) or placebo (n=296); a second randomization was performed to rosuvastatin (n=212) or placebo (n=207). Echocardiographic examinations were recorded at baseline and at 1, 2, and 3 years; offline analysis was performed by a core laboratory to ensure consistent quantitative analysis. Baseline LV ejection fraction (EF) was 30% (95%CI 29-31). Left ventricular ejection fraction increased with n-3 PUFA by 8.1% at 1 year, 11.1% at 2 years, and 11.5% at 3 years vs. 6.3% at 1 year, 8.2% at 2 years, and 9.9% at 3 years in the placebo group (P=0.0050). No other echocardiographic parameter changed significantly. Rosuvastatin effects were not statistically significant. CONCLUSION: n-3 PUFA can provide a small but statistically significant advantage in terms of LV function in patients with symptomatic HF of any aetiology, already treated with recommended therapies. |
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Authors:
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Stefano Ghio; Laura Scelsi; Roberto Latini; Serge Masson; Ermanno Eleuteri; Michela Palvarini; Olga Vriz; Michele Pasotti; Marco Gorini; Roberto Marchioli; Aldo Maggioni; Luigi Tavazzi; |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-10-16 |
Journal Detail:
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Title: European journal of heart failure Volume: 12 ISSN: 1879-0844 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-06-02 Revised Date: 2011-09-29 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1345-53 Citation Subset: IM |
Affiliation:
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Divisione di Cardiologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. s.ghio@smatteo.pv.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Fatty Acids, Omega-3 / pharmacology, therapeutic use* Female Fluorobenzenes / pharmacology, therapeutic use* Health Status Indicators Heart Failure / drug therapy*, pathology, ultrasonography Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology, therapeutic use* Male Prognosis Pyrimidines / pharmacology, therapeutic use* Stroke Volume / drug effects Sulfonamides / pharmacology, therapeutic use* Treatment Outcome Ventricular Function, Left / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 0/Fluorobenzenes; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrimidines; 0/Sulfonamides; 287714-41-4/rosuvastatin |
| Comments/Corrections | |
Erratum In:
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Eur J Heart Fail. 2011 Sep;13(9):1042 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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