| Effects of n-3 Long-Chain Polyunsaturated Fatty Acid Supplementation during Pregnancy and/or Lactation on Neurodevelopment and Visual Function in Children: A Systematic Review of Randomized Controlled Trials. | |
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MedLine Citation:
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PMID: 21504971 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To systematically evaluate the effects of n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) supplementation of pregnant and/or lactating women on the neurodevelopment and visual function of their children. METHODS: Systematic review. Randomized controlled trials (RCTs) comparing n-3 LCPUFA maternal supplementation were identified through electronic databases (MEDLINE, EMBASE, the Cochrane Library) and the references of reviewed articles. RESULTS: Overall, 13 publications, some with important methodological limitations, were included. With regard to supplementation during pregnancy, among 3 RCTs that evaluated this intervention, 1 RCT (n = 72) showed significantly better eye and hand coordination assessed with the Griffiths Mental Development Scales at 30 months of age. Another RCT (n = 29) demonstrated an effect of n-3 LCPUFA supplementation on the cloth step of intentional solutions of the 2-step problem-solving test. No other effects were demonstrated. There was no consistent effect of n-3 LCPUFA supplementation during pregnancy on the children's visual acuity. With regard to supplementation during lactation, among 3 RCTs that assessed this intervention, 1 RCT (n = 133) showed significant improvement on the Bayley Psychomotor Development Index in 30-month-old children; however, there was no influence of such supplementation on the results of different tests performed in the same group of children or in others. There was no consistent effect of n-3 LCPUFA supplementation during lactation on the children's visual function. Supplementation during pregnancy and lactation (3 RCTs) did not affect child neurodevelopment assessed up to 7 years of age. CONCLUSION: Evidence from RCTs does not demonstrate a clear and consistent benefit of n-3 LCPUFA supplementation during pregnancy and/or lactation on child neurodevelopment and visual acuity. These results should be interpreted with caution due to methodological limitations of the included studies. |
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Authors:
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Piotr Dziechciarz; Andrea Horvath; Hania Szajewska |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American College of Nutrition Volume: 29 ISSN: 1541-1087 ISO Abbreviation: J Am Coll Nutr Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2011-04-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8215879 Medline TA: J Am Coll Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 443-54 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, The Medical University of Warsaw, Dzialdowska 1, 01-184 Warsaw, POLAND, hania@ipgate.pl. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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