Document Detail

Effects of myocardial infarction on adrenergic nerves of the rat heart muscle, a histochemical study.
MedLine Citation:
PMID:  1146578     Owner:  NLM     Status:  MEDLINE    
The anterior branch of the left coronary artery of the rat heart was ligated and the effects of anoxia on adrenergic nerves were studied histochemically using formaldehyde-induced fluorescence for localization of norepinephrine. Greenish catecholamine fluorescence was associated in the normal or infarcted myocardium only with adrenergic nerves. Constant but not prominent changes were seen in adrenergic nerve fibers 2 or 4 h after ligation of the coronary artery; the number of dilicate adrenergic fibers was reduced and some diffusion of the histochemical reaction was seen in small areas of the infarcted myocardium. Strong effects of anoxia were seen 8 h or more after ligation of the coronary artery. These were characterized by a prominent diffusion of the histochemical reaction and gradual disappearance of adrenergic structures in 2 to 4 days of anoxia. During the healing phase the appearance of numerous adrenergic nerve fibers was closely connected with the ingrowth of a new vascular bed into the infarction area. The observations indicate that adrenergic nervous structures of the myocardium resist the effects of anoxia, which may indicate the viability of sympathetic nerves in the infarcted area during long periods of anoxia.
A Ahonen; M Härkönen; J Juntunen; M Kormano; A Penttilä
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  93     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1975 Mar 
Date Detail:
Created Date:  1975-09-29     Completed Date:  1975-09-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  336-44     Citation Subset:  IM    
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MeSH Terms
Catecholamines / metabolism
Coronary Vessels
Heart Ventricles / pathology
Microscopy, Fluorescence
Myocardial Infarction / metabolism*,  pathology
Myocardium / metabolism*,  pathology
Phosphorylases / metabolism
Sympathetic Nervous System / metabolism*,  pathology
Time Factors
Reg. No./Substance:
0/Catecholamines; EC 2.4.1.-/Phosphorylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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