Document Detail


Effects of myocardial contraction on coronary blood flow: an integrated model.
MedLine Citation:
PMID:  7872573     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of myocardial contraction on the coronary flow are studied by means of an integrated structural model of left ventricular (LV) mechanics, coronary flow, and fluid and mass transport. This model relates global LV performance, and in particular coronary flow dynamics, to myocardial composition and structure and contractile sarcomere activity. Extravascular pressure is identified with hydrostatic tissue pressure, i.e., intramyocardial pressure (IMP), and is determined by the dynamics of myocardial contraction and fluid transport. Consistent with available experimental data, changes in myocardial function and contractile state are simulated by changing the sarcomere contractile properties or changing the LV loading conditions. The model's predictions are successfully compared with a wide range of experimental studies; all but one were performed at a constant coronary perfusion pressure and maximal vasodilation. The results indicate a dominant effect of the myocardial contractile state on coronary flow and a dissociation between coronary compression and LV cavity pressure (LVP) when the pressure is controlled by load changes. However, when active sarcomere contraction is regionally impaired by lidocaine, LVP plays an important role in the coronary flow characteristics. The model adequately predicts observations on the effect of cardiac contraction on systolic and diastolic coronary flows, as well as the role of LVP at different loading and contractile conditions. The analysis supports the hypothesis that coronary compression, as mediated through IMP, is independent of LV loading conditions and depends on myocardial contractility and coronary perfusion pressure.
Authors:
D Zinemanas; R Beyar; S Sideman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  22     ISSN:  0090-6964     ISO Abbreviation:  Ann Biomed Eng     Publication Date:    1994 Nov-Dec
Date Detail:
Created Date:  1995-03-28     Completed Date:  1995-03-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  638-52     Citation Subset:  IM    
Affiliation:
Julius Silver Institute, Department of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa.
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MeSH Terms
Descriptor/Qualifier:
Biomechanics
Blood Pressure
Coronary Circulation*
Humans
Models, Cardiovascular*
Models, Structural
Myocardial Contraction*
Sarcomeres / physiology
Ventricular Function
Ventricular Pressure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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