| Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study. | |
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MedLine Citation:
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PMID: 20811299 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to evaluate whether myo-inositol, an insulin-sensitizing substance, may improve some features of metabolic syndrome in postmenopausal women. METHODS: Eighty postmenopausal women affected by the metabolic syndrome were enrolled prospectively in the study and treated with diet plus supplementation of myo-inositol (2 g BID plus diet: intervention group) or with diet plus placebo (control group) for 6 months. They were evaluated at baseline and after 6 months for insulin resistance (homeostasis model assessment ratio [HOMA] insulin resistance), lipid profile, and blood pressure. RESULTS: Myo-inositol plus diet improved systolic and diastolic blood pressure, HOMA index, cholesterol, and triglyceride serum levels with highly significant differences, compared with the groups treated only with diet and placebo. In the group treated with myo-inositol, a decrease in diastolic blood pressure (-11%), HOMA index (-75%), and serum triglycerides (-20%) and an improvement in high-density lipoprotein cholesterol (22%) were shown. CONCLUSIONS: Supplementation with myo-inositol may be considered a reliable option in the treatment of metabolic syndrome in postmenopausal women. |
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Authors:
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Domenico Giordano; Francesco Corrado; Angelo Santamaria; Simona Quattrone; Basilio Pintaudi; Antonino Di Benedetto; Rosario D'Anna |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Menopause (New York, N.Y.) Volume: 18 ISSN: 1530-0374 ISO Abbreviation: Menopause Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433353 Medline TA: Menopause Country: United States |
Other Details:
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Languages: eng Pagination: 102-4 Citation Subset: IM |
Affiliation:
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Policlinico Hospital, Reggio di Calabria, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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