Document Detail


Effects of moxonidine and metoprolol in penile circulation in hypertensive men with erectile dysfunction: results of a pilot study.
MedLine Citation:
PMID:  12934058     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Centrally acting (moxonidine) and peripherally acting (metoprolol) sympatholytic agents might have different actions upon penile circulation in hypertensive men with erectile dysfunction. A total of 11 nonsmoking, hypertensive but otherwise healthy men with erectile dysfunction were studied after 8 weeks on moxonidine monotherapy (0.4 mg per day, increased to 0.6 mg if needed) and then after 8 weeks of metoprolol monotherapy (100 mg per day, increased to 200 mg if needed) in a crossover design. At the end of each treatment phase, the subjects were asked about their subjective erectile capacity (nocturnal and coital erections), and resting and stimulated (after intracavernosal injection of a mixture of alprostadil and phentolamine) penile deep artery diameters and systolic peak velocities were measured by color Doppler ultrasonography. There were no significant differences in blood pressure after either therapy. The change from earlier antihypertensive therapy, moxonidine produced significant subjective amelioration of sexual dysfunction in 9/11 of the men (< or = 0.001), whereas 9/11 returned to impaired dysfunction after crossover to metoprolol treatment. Resting and stimulated deep penile diameters and peak systolic velocities were higher after moxonidine treatment compared with metoprolol (diameters: < or = 0.004, < or = 0.0001; velocities: < or = 0.008, < or = 0.038). The centrally acting sympatholytic agent moxonidine seems to improve erectile function both subjectively and objectively and has a better effect on penile circulation compared with the peripherally acting sympatholytic agent metoprolol.
Authors:
J Piha; R Kaaja
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of impotence research     Volume:  15     ISSN:  0955-9930     ISO Abbreviation:  Int. J. Impot. Res.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-22     Completed Date:  2003-10-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007383     Medline TA:  Int J Impot Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  287-9     Citation Subset:  IM    
Affiliation:
Mehilainen Co, Erectile Dysfunction Clinic, Turku, Finland. juhana.piha@pp.fimnet.fi
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MeSH Terms
Descriptor/Qualifier:
Adult
Antihypertensive Agents / therapeutic use
Arteries
Blood Flow Velocity / drug effects
Cross-Over Studies
Drug Administration Schedule
Erectile Dysfunction / drug therapy*,  etiology*
Humans
Hypertension / complications*,  drug therapy
Imidazoles / administration & dosage*
Male
Metoprolol / administration & dosage*
Middle Aged
Penis / blood supply*,  ultrasonography
Pilot Projects
Regional Blood Flow / drug effects
Sympatholytics / administration & dosage*
Ultrasonography, Doppler
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Imidazoles; 0/Sympatholytics; 37350-58-6/Metoprolol; 75438-57-2/moxonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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