| Effects of movement and work load in patients with congenital central hypoventilation syndrome. | |
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MedLine Citation:
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PMID: 17446810 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patients with congenital central hypoventilation syndrome lack ventilatory chemosensitivity and depend at least in part on the ergoreceptor function during exercise. In these patients a substantial increase of ventilation has been reported for passive movement during sleep as well as active movement on a treadmill. OBJECTIVES: The aim of the study was to investigate ventilatory response to an increasing work load with constant movement. METHODS AND RESULTS: Eighteen patients and 17 healthy volunteers performed a cardiopulmonary exercise test on a bicycle pedaling at a constant rate of about 60 revolutions per minute throughout the entire test. The patients were able to exercise adequately and showed normal peak oxygen uptake. There was a steep rise in minute ventilation in both groups at the start of exercise, yet there was only a minor increase in both groups during the increase of workload up to the anaerobic threshold. After the anaerobic threshold, there was again an increase in ventilation in both groups, but the increase was less prominent in the patient group. CONCLUSIONS: Ventilation in patients with congenital central hypoventilation syndrome is increased during exercise caused both by movement (mechanoreceptors) and by anaerobic workload. This facilitates a normal ventilatory drive up to the anaerobic threshold and a normal exercise capacity in these patients. |
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Authors:
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Alfred Hager; Walter Koch; Heike Stenzel; John Hess; Johannes Schöber |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Volume: 14 ISSN: 1741-8267 ISO Abbreviation: Eur J Cardiovasc Prev Rehabil Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-20 Completed Date: 2007-09-20 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101192000 Medline TA: Eur J Cardiovasc Prev Rehabil Country: England |
Other Details:
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Languages: eng Pagination: 294-8 Citation Subset: IM |
Affiliation:
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Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich, Technical University of Munich, Munich, Germany. a-hager@web.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anaerobic Threshold* Case-Control Studies Child Exercise Test Female Follow-Up Studies Humans Male Movement* Physical Exertion* Respiration Sleep Apnea, Central / congenital*, physiopathology* Tidal Volume |
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