Document Detail


Effects of mothers' prenatal psychiatric status and postnatal caregiving on infant biobehavioral regulation: can prenatal programming be modified?
MedLine Citation:
PMID:  17761394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Animal research suggests that antenatal stress exposure and postnatal rearing style act in concert to shape offspring biobehavioral outcomes. However, the combination of these maternally-mediated influences has not been studied in human infants.
AIMS: To examine antenatal psychiatric status and maternal sensitivity in relation to 4-month-olds' autonomic regulation, HPA-axis functioning, and behavior.
STUDY DESIGN: Prospective study of 47 pregnant women recruited from an urban hospital who completed questionnaire measures of anxiety and depression and underwent a psychiatric interview in the 2nd trimester. At 4 months postpartum, women again completed mood questionnaires and the mother-infant dyads participated in a 10-minute free-play session evaluated for maternal sensitivity.
OUTCOME MEASURES: Baseline infant salivary cortisol and electrocardiogram (EKG) collected at the start of the 4-month sessions. Infant responsiveness and maternal report of temperament also were evaluated.
RESULTS: Maternal sensitivity, but not antenatal psychiatric diagnosis, predicted greater levels of infant high frequency heart rate variability, after controlling for birth weight and age. Maternal sensitivity, but not psychiatric status, also predicted infant responsiveness. Maternal sensitivity modulated the effects of psychiatric illness on infant cortisol such that cortisol was low regardless of sensitivity for children of healthy women yet higher if the infant had insensitive versus sensitive caregiving when the mother had had an antenatal diagnosis.
CONCLUSIONS: Biobehavioral adaptation, even that initiated in utero, is influenced by interactions with the social world. These findings support the compatibility of fetal programming and social-context models of infant biobehavioral development and have promising implications for pre and postnatal clinical intervention.
Authors:
Lauren A Kaplan; Lynn Evans; Catherine Monk
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-08-30
Journal Detail:
Title:  Early human development     Volume:  84     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-14     Completed Date:  2008-06-24     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  249-56     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Child Development / physiology*
Female
Humans
Hydrocortisone / metabolism
Infant
Infant Behavior / physiology*,  psychology
Male
Maternal Behavior / psychology*
Mother-Child Relations*
Pregnancy
Prenatal Care*
Prospective Studies
Saliva / chemistry
Temperament / physiology*
Grant Support
ID/Acronym/Agency:
K23 MH001928/MH/NIMH NIH HHS; K23 MH001928-05/MH/NIMH NIH HHS; MH 01928/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
WI4X0X7BPJ/Hydrocortisone
Comments/Corrections

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