Document Detail


Effects of mosapride on esophageal secondary peristalsis in humans.
MedLine Citation:
PMID:  21501334     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background  Secondary peristalsis is important for the clearance of refluxate or retained food bolus from the esophagus. Mosapride is a prokinetic agent that enhances GI motility by stimulating 5-hydroxytrypatamine(4) (5-HT(4) ) receptors, but its effects on secondary peristalsis are yet unclear in humans. We aimed to investigate the effect of a 5-HT(4) agonist mosapride on esophageal distension-induced secondary peristalsis in normal subjects. Methods  After a baseline recording esophageal motility, secondary peristalsis was generated by slow and rapid mid-esophageal injections of air in 15 healthy subjects. Two separate sessions with 40 mg oral mosapride or placebo were randomly performed to test their effects on esophageal secondary peristalsis. Key Results  Mosapride decreased the threshold volume for triggering secondary peristalsis during rapid air distension (4.5 ± 0.3 vs 5.3 ± 0.4 mL; P = 0.04) but not slow air distension (14.3 ± 1.2 vs 13.3 ± 1.3 mL; P = 0.41). Secondary peristalsis was triggered more frequently in response to rapid air distension after application of mosapride [100% (90-100%) vs 90% (80-100%); P = 0.02]. Mosapride significantly increased pressure wave amplitudes of secondary peristalsis during slow (135.4 ± 13.8 vs 105.0 ± 12.9 mmHg; P = 0.001) and rapid air distensions (124.0 ± 11.6 vs 95.9 ± 14.0 mmHg; P = 0.002). Conclusions & Inferences  Mosapride enhances sensitivity to distension-induced secondary peristalsis and facilitates secondary peristaltic contractility. These data provide an evidence for modulation of esophageal secondary peristalsis by the 5-HT(4) agonist mosapride, as well support for its clinical utility.
Authors:
C L Chen; T T Liu; C H Yi; W C Orr
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-19
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  -     ISSN:  1365-2982     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Affiliation:
Department of Medicine, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan Lynn Health Science Institute, Oklahoma University Health Sciences Center, Oklahoma City, OK, USA.
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