Document Detail

Effects of morphine and physostigmine on the ventilatory response to carbon dioxide.
MedLine Citation:
PMID:  8010477     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has been reported that physostigmine antagonizes morphine-induced respiratory depression, but it is not known whether this is due to a central chemoreceptor effect, an effect on the peripheral chemoreflex loop, or both. We therefore assessed the effect of morphine and physostigmine on the normoxic hypercapnic ventilatory response mediated by the central and peripheral chemoreceptors in ten alpha-chloralose-urethan-anesthetized cats. METHODS: The breath-by-breath ventilatory responses to stepwise changes in end-tidal CO2 tension were determined before (control), after administration of morphine hydrochloride (0.15 and during intravenous infusion of physostigmine salicylate (bolus of 0.05 followed by 0.025 Each response was separated into a central and a peripheral chemoreflex characterized by CO2 sensitivity (Sc and Sp), time constant, time delay, and apneic threshold (a single off-set B). RESULTS: Morphine increased B and decreased Sc and Sp (P < 0.01), but not the ratio Sp/Sc. Subsequent infusion of physostigmine decreased B (P < 0.01), without further change of Sp and Sc. Premedication with physostigmine decreased B, Sp and Sc (P < 0.01) vs. control, but not Sp/Sc. Subsequent administration of morphine decreased Sp and Sc further but increased B (P < 0.01), while Sp/Sc remained constant. CONCLUSIONS: Because morphine diminishes the Sc and Sp of the chemoreflex loop to the same extent this depressant effect is presumably due to an action on the respiratory integrating centers rather than on the peripheral and central chemoreceptors as such and is not antagonized by physostigmine. We argue that the increase in B may be due to changes in the amount of acetylcholine available in the brain and can be antagonized by physostigmine.
A Berkenbosch; C N Olievier; J G Wolsink; J DeGoede; J Rupreht
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesiology     Volume:  80     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-18     Completed Date:  1994-07-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1303-10     Citation Subset:  AIM; IM    
Department of Physiology, University of Leiden, The Netherlands.
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MeSH Terms
Carbon Dioxide / antagonists & inhibitors*,  pharmacology
Chemoreceptor Cells / drug effects*
Morphine / pharmacology*
Naloxone / pharmacology
Physostigmine / pharmacology*
Respiration / drug effects*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 465-65-6/Naloxone; 57-27-2/Morphine; 57-47-6/Physostigmine

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