Document Detail

Effects of morphine on the electroencephalograms of neonates: a prospective, observational study.
MedLine Citation:
PMID:  11068229     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Although opiates have been reported to profoundly alter the EEG and cause seizures in full-term and premature newborn babies, no prospective study has systematically studied the effects of morphine on the EEG of normal neonates. METHODS: A prospective observational study was conducted on 20 neurologically and metabolically normal newborn babies of > or =26 weeks post-conceptional age, with EEG recordings performed while on and off morphine infusions. RESULTS: The recordings performed while the babies were on morphine were all abnormal; the principal abnormalities consisted of prolonged periods of electrical quiescence (PPEQs) and excessive interictal epileptiform activity. After the morphine was discontinued, the PPEQs resolved and the EEG background rhythms were normal for age, but 5 continued to have excessive sharp transients. All babies did well clinically and did not require anti-epileptic drug therapy. CONCLUSIONS: Morphine produces a profound, largely reversible alteration of all neonatal EEGs at various post-conceptional ages. The study has implications for caution in formulating conclusions regarding the clinical significance of EEGs of critically ill neonates on morphine infusions.
G B Young; O P da Silva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  111     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-12-15     Completed Date:  2001-01-11     Revised Date:  2008-09-10    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1955-60     Citation Subset:  IM    
University of Western Ontario, Ontario, London, Canada.
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MeSH Terms
Brain / drug effects*,  physiology*
Electroencephalography / drug effects*
Infant, Newborn
Morphine / pharmacology*
Prospective Studies
Reference Values
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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