| Effects of morphine on acquisition and maintenance of ethanol and water intake patterns in rats. | |
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MedLine Citation:
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PMID: 1418670 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two experiments were conducted to assess the effects of chronic subcutaneous injections of morphine (1.0 mg/kg) or saline on the pattern and amount of sweetened ethanol and water intake in fluid restricted Long-Evans rats. Following daily injections, 2-h two-bottle choice tests were conducted with water and an ethanol solution (15% ethanol v/v in 5% sucrose w/v). During a 20-day acquisition phase (Experiment 1), ethanol intake patterns and amounts did not differ between saline (n = 6) and morphine (n = 6) groups. Both groups exhibited ethanol intake patterns that decreased exponentially throughout the session suggesting control by fluid restriction procedures. Morphine decreased water intake during initial periods of each session and increased intake during later periods. In Experiment 2, morphine and saline injections were reversed across three phases with the same rats. Morphine increased total ethanol consumption during the first few days of each 15-day phase, but the groups did not differ thereafter, and the initial increases produced no statistically significant group differences. Additionally, morphine augmented ethanol intake in early portions of sessions, while water intake was decreased and increased during early and later portions of each session, respectively. Analysis of the data from the last 5 days of each phase indicated that, when injected with morphine, the group which received saline during acquisition consumed significantly more ethanol solution than the group injected with morphine during acquisition. The effect on patterns of water and ethanol intake were observed, regardless of the drug injected during acquisition.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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C W Hodge; C M Andrews; R S Lewis; H H Samson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Alcohol (Fayetteville, N.Y.) Volume: 9 ISSN: 0741-8329 ISO Abbreviation: Alcohol Publication Date: 1992 Sep-Oct |
Date Detail:
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Created Date: 1992-12-10 Completed Date: 1992-12-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8502311 Medline TA: Alcohol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 433-40 Citation Subset: IM |
Affiliation:
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Alcohol and Drug Abuse Institute, University of Washington, Seattle 98195. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking* Animals Dopamine / physiology Drinking / drug effects* Male Morphine / pharmacology* Rats |
| Grant Support | |
ID/Acronym/Agency:
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AA07455-07/AA/NIAAA NIH HHS; R01 AA 06845/AA/NIAAA NIH HHS; R01 AA07404/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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