| Effects of montelukast and zileuton on testicular torsion/detorsion injury in rats. | |
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MedLine Citation:
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PMID: 23137139 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aim of this study was to evaluate and compare the effects of 5-lipoxygenase enzyme (5-LO) inhibitor zileuton and cysteinyl leukotrienes receptor (CysLT1R) antagonist montelukast in testicular torsion/detorsion (T/D) injury model in rats. Rats were anesthetised with 75 mg kg(-1) ketamine hydrochloride and 8 mg kg(-1) xylazine intraperitoneal before the operation. Torsion was created by rotating the right testis 720° clockwise and maintained by fixing the testis. The rats were treated with CysLT1R antagonist montelukast (10 mg kg(-1) ; i.p.), 5-LO inhibitor zileuton (3 mg kg(-1) ; i.p.), and vehicle, at 30 min prior detorsion. After 1 h of torsion, the testis was counter-rotated to the natural position and replaced into the scrotum. Malondialdehyde (MDA) level was measured in testicular tissue after 3 h of reperfusion. Histological examination was performed after 24 h of reperfusion. T/D caused a significant increase in MDA level and histopathological injury in testes. Montelukast and zileuton treatments prevented the T/D-induced augmentation in MDA levels. Only, zileuton treatment significantly reduced the T/D-induced histopathological injury. In this study, we demonstrated for the first time that zileuton had protective effects on testicular T/D injury. We have also found that zileuton is more effective than montelukast on histopathological injury. |
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Authors:
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F Isikdemir; Z Kurcer; G O Dengiz; E Y Sipahi; Z N Banoglu; F Baba; S Acikgoz; S Kelek |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-9 |
Journal Detail:
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Title: Andrologia Volume: - ISSN: 1439-0272 ISO Abbreviation: Andrologia Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0423506 Medline TA: Andrologia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Blackwell Verlag GmbH. |
Affiliation:
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Department of Pharmacology, Faculty of Medicine, Bulent Ecevit University, Zonguldak, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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