Document Detail


Effects of montelukast and salmeterol on physical performance and exercise economy in adult asthmatics with exercise-induced bronchoconstriction.
MedLine Citation:
PMID:  15486377     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STUDY OBJECTIVES: To compare the effect of montelukast and the long-acting beta(2)-agonist salmeterol on cardiopulmonary exercise economy and physical performance in adult patients with asthma during exercise. DESIGN AND PATIENTS: Asthmatic patients (n = 18), aged 18 to 35 years with exercise-induced bronchoconstriction (EIB), using a double-blind, double-dummy cross-over design. Montelukast, 10 mg/d, was compared to inhaled salmeterol, 50 microg bid. The study medication was administered for at least 5 days prior to testing, with a washout period of at least 5 days. Treadmill exercise tests (5.3% inclination, -15 degrees C ambient temperature) were performed at work loads of 80% of maximal oxygen uptake (Vo(2)max) [6 min], rest (4 min), 60% of Vo(2)max (6 min), and finally step increments until exhaustion. MEASUREMENTS AND RESULTS: We investigated parameters of gas exchange, physical performance, and lung function. After montelukast, the oxygen pulse was higher than after salmeterol, at 80% of Vo(2)max (p = 0.035), and 6 min at 60% of Vo(2)max (p = 0.011). Lung function during exercise, running time to exhaustion, Borg score, lactate levels, Vo(2)max, carbon dioxide elimination, minute ventilation, ventilatory equivalents, respiratory exchange ratio, and heart rate were not significantly different between the two treatments. The maximal postexercise fall in FEV(1) from baseline occurred 2 min after run to exhaustion, and was greater after salmeterol than after montelukast: mean, 16.2% (SD, 11.0) vs 10.0% (SD, 12.2) [p < 0.001]. CONCLUSIONS: In adult asthmatics with EIB, montelukast may have a more favorable effect on the oxygen pulse, thus suggesting improved gas exchange during exercise.
Authors:
Sigurd Steinshamn; Mariann Sandsund; Malcolm Sue-Chu; Leif Bjermer
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  126     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-15     Completed Date:  2004-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1154-60     Citation Subset:  AIM; IM    
Affiliation:
Department of Lung Medicine, Heart and Lung Institute, University Hospital of Trondheim, N-7006 Trondheim, Norway. sigurd.steinshamn@medisin.ntnu.no
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MeSH Terms
Descriptor/Qualifier:
Acetates / pharmacology*
Adolescent
Adrenergic beta-Agonists / pharmacology*
Adult
Albuterol / analogs & derivatives*,  pharmacology*
Anti-Asthmatic Agents / pharmacology*
Asthma, Exercise-Induced / physiopathology*
Bronchoconstriction*
Cross-Over Studies
Double-Blind Method
Female
Forced Expiratory Volume / drug effects
Humans
Lactates / analysis
Male
Pulmonary Gas Exchange / drug effects
Quinolines / pharmacology*
Chemical
Reg. No./Substance:
0/Acetates; 0/Adrenergic beta-Agonists; 0/Anti-Asthmatic Agents; 0/Lactates; 0/Quinolines; 158966-92-8/montelukast; 18559-94-9/Albuterol; 89365-50-4/salmeterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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