Document Detail

Effects of monounsaturated vs. saturated fat on postprandial lipemia and adipose tissue lipases in type 2 diabetes.
MedLine Citation:
PMID:  17765364     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The effects of different dietary fatty acids on postprandial lipid metabolism in type 2 diabetic patients are still debated. AIM: To evaluate the effects of monounsaturated (MUFA) vs. saturated fat (SAFA)-rich diets on postprandial lipemia and adipose tissue lipoprotein lipase (LPL), and hormone-sensitive lipase (HSL) in type 2 diabetes. MATERIALS AND METHODS: Eleven type 2 diabetic patients followed, in random order, a diet rich in MUFA (SAFA 8%, MUFA 23%) and another rich in SAFA (SAFA 17%, MUFA 15%) for a period of 3 weeks each. At the end of the two diets, a standard fat-rich meal was administered and subcutaneous fat biopsies were performed at fasting and 6h after the test meal. RESULTS: Neither diet induced significant changes in meal lipid tolerance, except for a faster (at 2h) increase in chylomicron triglycerides and a significant decrease in small VLDL triglyceride incremental area after the MUFA diet (-13.6+/-4.7 mg/dl*6h vs. -2.2+/-3.7 mg/dl*6h, p<0.005) (M+/-SEM). LPL and HSL activities were significantly increased after the MUFA diet. CONCLUSIONS: A MUFA-rich diet reduces postprandial small VLDL triglycerides in type 2 diabetic patients compared to a SAFA-rich diet, and modifies lipolytic enzymes in adipose tissue.
Angela A Rivellese; Rosalba Giacco; Giovanni Annuzzi; Claudia De Natale; Lidia Patti; Lucrezia Di Marino; Valentina Minerva; Giuseppina Costabile; Carmela Santangelo; Roberta Masella; Gabriele Riccardi
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-08-31
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  27     ISSN:  1532-1983     ISO Abbreviation:  Clin Nutr     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-12     Completed Date:  2008-03-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  133-41     Citation Subset:  IM    
Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy.
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MeSH Terms
Adipose Tissue / enzymology
Area Under Curve
Cross-Over Studies
Diabetes Mellitus, Type 2 / blood,  metabolism*
Dietary Fats / administration & dosage*
Dietary Fats, Unsaturated / administration & dosage*
Dose-Response Relationship, Drug
Lipase / metabolism*
Lipid Metabolism / drug effects*
Lipoprotein Lipase / metabolism
Middle Aged
Particle Size
Postprandial Period
Sterol Esterase / metabolism
Triglycerides / metabolism
Reg. No./Substance:
0/Dietary Fats; 0/Dietary Fats, Unsaturated; 0/Triglycerides; EC Esterase; EC; EC Lipase

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