| Effects of monosodium glutamate supplementation on glutamine metabolism in adult rats. | |
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MedLine Citation:
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PMID: 21196308 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Monosodium glutamate (MSG) is a worldwide used flavor enhancer. Supplemental glutamate may impact physiological functions. The aim of this study was to document the metabolic and physiological consequences of supplementation with 2% MSG (w/w) in rats. After 15 days-supplementation and following the ingestion of a test meal containing 2% MSG, glutamic acid accumulated for 5h in the stomach and for 1h in the small intestine. This coincided with a significant decrease of intestinal glutaminase activity, a marked specific increase in plasma glutamine concentration and a transient increase of plasma insulin concentration. MSG after chronic or acute supplementation had no effect on food intake, body weight, adipose tissue masses, gastric emptying rate, incorporation of dietary nitrogen in gastrointestinal and other tissues, and protein synthesis in intestinal mucosa, liver and muscles. The only significant effects of chronic supplementation were a slightly diminished gastrocnemius muscle mass, increased protein mass in intestinal mucosa and decreased protein synthesis in stomach. It is concluded that MSG chronic supplementation promotes glutamine synthesis in the body but has little effect on the physiological functions examined. |
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Authors:
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Claire Boutry; Cecile Bos; Hideki Matsumoto; Patrick Even; Dalila Azzout-Marniche; Daniel Tome; Francois Blachier |
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Publication Detail:
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Type: Journal Article Date: 2011-01-01 |
Journal Detail:
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Title: Frontiers in bioscience (Elite edition) Volume: 3 ISSN: 1945-0508 ISO Abbreviation: Front Biosci (Elite Ed) Publication Date: 2011 |
Date Detail:
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Created Date: 2011-01-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101485240 Medline TA: Front Biosci (Elite Ed) Country: United States |
Other Details:
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Languages: eng Pagination: 279-90 Citation Subset: IM |
Affiliation:
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INRA, CNRH-IdF, UMR 914 Nutrition Physiology and Ingestive Behavior, Paris, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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