Document Detail


Effects of monoclonal anticardiolipin antibody on pregnant mice.
MedLine Citation:
PMID:  8838513     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To clarify the effects of anticardiolipin antibodies (aCL) on pregnancy. METHODS: Monoclonal aCL obtained from MRL/lpr mice was administered to pregnant BALB/c mice and changes in the outcome of pregnancy were evaluated. RESULTS: The pregnant BALB/c mice injected with monoclonal aCL showed a higher intrauterine fetal death rate than controls, but there were no significant differences in platelet counts. We observed signs of placental infarction only in the placenta of the treated pregnant BALB/c mice. CONCLUSION: The intrauterine fetal deaths may have been due to thrombosis.
Authors:
T Suzuki; K Takabayashi; K Ichikawa; I Itou; N Ishiguro; T Yoshiki; T Koike
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  23     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-12-12     Completed Date:  1996-12-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  83-6     Citation Subset:  IM    
Affiliation:
Second Department of Internal Medicine, Chiba University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Anticardiolipin / immunology,  pharmacology*
Antibodies, Monoclonal / chemistry,  pharmacology*
Blood Vessels / pathology
Female
Fetal Death / chemically induced
Male
Mice
Mice, Inbred BALB C
Mice, Inbred ICR
Necrosis
Platelet Count / drug effects
Pregnancy
Pregnancy, Animal / drug effects*,  immunology
Thrombosis / etiology
Chemical
Reg. No./Substance:
0/Antibodies, Anticardiolipin; 0/Antibodies, Monoclonal

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