Document Detail


Effects of monoamine releasers with varying selectivity for releasing dopamine/norepinephrine versus serotonin on choice between cocaine and food in rhesus monkeys.
MedLine Citation:
PMID:  22015808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Monoamine releasers constitute one class of candidate medications for the treatment of cocaine abuse, and concurrent cocaine-versus-food choice procedures are potentially valuable as experimental tools to evaluate the efficacy and safety of candidate medications. This study assessed the choice between cocaine and food by rhesus monkeys during treatment with five monoamine releasers that varied in selectivity to promote the release of dopamine and norepinephrine versus serotonin (5HT) [m-fluoroamphetamine, (+)-phenmetrazine, (+)-methamphetamine, napthylisopropylamine and (±)-fenfluramine]. Rhesus monkeys (n=8) responded under a concurrent-choice schedule of food delivery (1-g pellets, fixed ratio 100 schedule) and cocaine injections (0-0.1 mg/kg/injection, fixed ratio 10 schedule). Cocaine choice dose-effect curves were determined daily during continuous 7-day treatment with saline or with each test compound dose. During saline treatment, cocaine maintained a dose-dependent increase in cocaine choice, and the highest cocaine doses (0.032-0.1 mg/kg/injection) maintained almost exclusive cocaine choice. Efficacy of monoamine releasers to decrease cocaine choice corresponded to their pharmacological selectivity to release dopamine and norepinephrine versus 5HT. None of the releasers reduced cocaine choice or promoted reallocation of responding to food choice to the same extent as when saline was substituted for cocaine. These results extend the range of conditions across which dopamine and norepinephrine-selective releasers have been shown to reduce cocaine self-administration.
Authors:
Matthew L Banks; Bruce E Blough; S Stevens Negus
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Behavioural pharmacology     Volume:  22     ISSN:  1473-5849     ISO Abbreviation:  Behav Pharmacol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-09     Completed Date:  2013-02-05     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  824-36     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenergic Agents / pharmacology*
Amphetamine / pharmacology
Animals
Behavior, Animal / drug effects*
Choice Behavior / drug effects*
Cocaine / administration & dosage*
Dopamine Agents / pharmacology*
Dose-Response Relationship, Drug
Food
Macaca mulatta
Male
Methamphetamine / pharmacology
Phenmetrazine / pharmacology
Reinforcement Schedule
Self Administration
Serotonin Agents / pharmacology*
Grant Support
ID/Acronym/Agency:
R01 DA012970/DA/NIDA NIH HHS; R01 DA012970-10/DA/NIDA NIH HHS; R01 DA012970-11/DA/NIDA NIH HHS; R01 DA026946/DA/NIDA NIH HHS; R01 DA026946-01/DA/NIDA NIH HHS; R01 DA026946-02/DA/NIDA NIH HHS; R01 DA026946-03/DA/NIDA NIH HHS; R01 DA026946-04/DA/NIDA NIH HHS; R01-DA012790/DA/NIDA NIH HHS; R01-DA26946/DA/NIDA NIH HHS; T32 DA007027/DA/NIDA NIH HHS; T32 DA007027-31/DA/NIDA NIH HHS; T32 DA007027-32/DA/NIDA NIH HHS; T32-DA07027/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic Agents; 0/Dopamine Agents; 0/Serotonin Agents; 44RAL3456C/Methamphetamine; CK833KGX7E/Amphetamine; I5Y540LHVR/Cocaine; XA501VL3VR/Phenmetrazine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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