| Effects of modified hemoglobin solutions on the isolated rabbit heart. | |
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MedLine Citation:
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PMID: 1391498 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of modified hemoglobin (Hb) solutions on the coronary vasculature were studied. Hearts were perfused according to Langendorff with constant flow of Tyrode solution. The solutions studied were stroma- free Hb, prepared by lysis of red blood cells in water (SFHb-lys), or prepared by swelling of red blood cells in hypotonic phosphate buffer (SFHb). The increase in coronary vascular resistance at a dose of 200 mg Hb/dl was 68% for SFHb-lys and 13% for SFHb, respectively. Addition of the modified Hb solutions HbNFPLP and polyHbNFPLP produced an increase in coronary resistance of 11% and 8%, respectively. The left ventricular developed pressure (LVDP) (control value 72 +/- 12 mm Hg) increased by 18 and 12 mm Hg, respectively, for a dose of 250 mg Hb/dl. When HbNFPLP was converted to its met-Hb form the increase in LVDP was reduced to 3 mmHg and the increase in perfusion pressure to 6 mm Hg. We conclude that elimination of stromal contamination from Hb solutions can diminish vasoconstrictor effects. The increase in cardiac pressure development and in coronary vascular resistance found for dilute modified Hb solutions is partly due to an improved oxygen transport to the heart. |
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Authors:
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P T Biessels; J B Hak; W K Bleeker; J H van Beek; J C Bakker |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Volume: 20 ISSN: 1055-7172 ISO Abbreviation: Biomater Artif Cells Immobilization Biotechnol Publication Date: 1992 |
Date Detail:
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Created Date: 1992-11-18 Completed Date: 1992-11-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111988 Medline TA: Biomater Artif Cells Immobilization Biotechnol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 693-6 Citation Subset: IM |
Affiliation:
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Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Amsterdam. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Blood Substitutes / pharmacology* Heart / drug effects*, physiology Hemoglobins / pharmacology* Oxygen / blood Pyridoxal Phosphate / analogs & derivatives, pharmacology Rabbits Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Blood Substitutes; 0/Hemoglobins; 0/hemoglobin, stroma free; 0/polyhemoglobin; 0/polyhemoglobin-pyridoxal-5-phosphate; 54-47-7/Pyridoxal Phosphate; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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