Document Detail


Effects of modest testosterone supplementation and exercise for 12 weeks on body composition and quality of life in elderly men.
MedLine Citation:
PMID:  17132757     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: One of the factors that may promote deterioration in quality of life and body composition in elderly men is the relative decline in serum testosterone levels with aging. In this study, we assessed the effects of modest doses of testosterone and a home-based strengthening program on quality of life and body composition in elderly men with relative testosterone insufficiency. DESIGN: Double-blind, placebo-controlled randomized study (testosterone), and additional randomization to a resistance exercise program or no additional exercise for 12 weeks in men between ages of 65 and 85 years with relative testosterone insufficiency. METHODS: Seventy sedentary, community dwelling men were randomized to a 5 mg testoderm transdermal system applied daily vs placebo system, and additionally randomized to a home-based resistance exercise program. Subjects were randomized to Group 1 (testosterone plus exercise), Group 2 (testosterone plus no exercise), Group 3 (placebo plus exercise), and Group 4 (placebo plus no exercise). Endpoints included quality of life (assessed by the short form-36 questionnaire) and body composition (measured by dual x-ray absorptiometry scan). RESULTS: Serum testosterone increased by a mean of 10.0 +/- 1.9, 6.6 +/- 1.6, 0.52 +/- 0.6, and 0.5 +/- 0.6 nmol/l in Groups 1, 2, 3, and 4 respectively. There was a significant interaction of testosterone and exercise on quality of life in the domains of physical functioning (P = 0.03), role physical (P = 0.01), general health (P = 0.049), and social functioning (P = 0.04). There were no effects of testosterone or exercise on quality of life alone, nor in body composition parameters. CONCLUSIONS: Modest testosterone supplementation to elderly men with relative testosterone insufficiency improved quality of life when accompanied by an exercise program. The combination of testosterone and exercise may be an important strategy in the elderly, though further studies are necessary to determine the long-term impact on body composition and function and for analysis of risk/benefit ratios as well.
Authors:
Laurence Katznelson; Mara W Robinson; Caryn L Coyle; Hang Lee; Christina E Farrell
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  155     ISSN:  0804-4643     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-29     Completed Date:  2007-02-16     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  867-75     Citation Subset:  IM    
Affiliation:
Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. lkatznelson@stanford.edu
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Aged
Aged, 80 and over
Androgens / administration & dosage*,  adverse effects,  blood
Body Composition / drug effects
Combined Modality Therapy
Exercise*
Humans
Hypogonadism / drug therapy*,  psychology
Male
Quality of Life*
Testosterone / administration & dosage*,  adverse effects,  blood
Treatment Outcome
Grant Support
ID/Acronym/Agency:
M01-RR-01066/RR/NCRR NIH HHS; R29 AG15882-04/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Androgens; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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