| Effects of moderate low sodium/high potassium diet on essential hypertension: results of a comparative study. | |
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MedLine Citation:
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PMID: 3045025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is generally accepted that a significant restriction in sodium intake can lower blood pressure in hypertensive patients and more recently it has also been suggested that a high potassium intake can exert an antihypertensive effect. We have therefore, conducted a double-blind, randomized, cross-over study to evaluate the antihypertensive efficacy of the combination of a modest dietary sodium restriction and a high potassium intake in hypertensive patients of mild and moderate degrees. During the modest sodium (100 mmol/day)/high potassium (130 mmol/day) diet the blood pressure was significantly reduced (-17/-6 mmHg) when compared to the normal diet (160 mmol Na/day and 80 mmol K/day). The blood pressure reduction did not interfere with hemodynamic and humoral responses to dynamic exercise. The modest reduction in sodium intake and increase in potassium content in the diet was well tolerated by the patients. |
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Authors:
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G D Bompiani; G Cerasola; M L Morici; M Condorelli; B Trimarco; N De Luca; G Leonetti; L Sampieri; C Cuspidi; S Cottone |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: International journal of clinical pharmacology, therapy, and toxicology Volume: 26 ISSN: 0174-4879 ISO Abbreviation: Int J Clin Pharmacol Ther Toxicol Publication Date: 1988 Mar |
Date Detail:
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Created Date: 1988-09-29 Completed Date: 1988-09-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8003415 Medline TA: Int J Clin Pharmacol Ther Toxicol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 129-32 Citation Subset: IM |
Affiliation:
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First Medical Clinic, University of Palermo, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aldosterone / blood Blood Pressure / drug effects Body Weight Clinical Trials as Topic Diet Double-Blind Method Electrolytes / blood Female Humans Hypertension / blood, diet therapy*, physiopathology Male Norepinephrine / blood Potassium / administration & dosage* Random Allocation Renin / blood Sodium, Dietary* |
| Chemical | |
Reg. No./Substance:
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0/Electrolytes; 0/Sodium, Dietary; 51-41-2/Norepinephrine; 52-39-1/Aldosterone; 7440-09-7/Potassium; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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