Document Detail

Effects of moderate increases in dietary polyunsaturated: saturated fat on plasma triglyceride and cholesterol levels in man.
MedLine Citation:
PMID:  7066289     Owner:  NLM     Status:  MEDLINE    
1. The effects of two isoenergetic diets differing only in the values for polyunsaturated: saturated fat (P:S values of 0.2 v. 2.0) were studied in twenty adult human volunteers. 2. A period of 14 d on the high P:S diet failed to produce significant changes in fasting triglyceride levels, though there were individual variations. On the other hand, fasting cholesterol levels dropped by 10% (P less than 0.005). High-density-lipoprotein-cholesterol concentrations were not influenced by changes in the P:S value. 3. Investigations into the mechanism by which changes in the P:S value might affect plasma triglyceride values revealed no consistent effects on very-low-density-lipoprotein kinetics, insulin secretion, insulin sensitivity or free fatty acid concentrations. 4. The results of this study suggest that the largest increase in dietary P:S values that is likely to be obtained on a long-term basis may have only a small effect on plasma triglyceride and cholesterol concentrations.
F B Kraemer; M Greenfield; T A Tobey; G M Reaven
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The British journal of nutrition     Volume:  47     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-06-21     Completed Date:  1982-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  259-66     Citation Subset:  IM    
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MeSH Terms
Cholesterol / blood*
Cholesterol, HDL
Dietary Fats / administration & dosage*
Dose-Response Relationship, Drug
Fats, Unsaturated / administration & dosage
Lipoproteins, HDL / blood
Lipoproteins, VLDL / blood
Middle Aged
Structure-Activity Relationship
Triglycerides / blood*
Reg. No./Substance:
0/Cholesterol, HDL; 0/Dietary Fats; 0/Fats, Unsaturated; 0/Lipoproteins, HDL; 0/Lipoproteins, VLDL; 0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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