Document Detail

Effects of moderate heart failure and functional overload on rat plantaris muscle.
MedLine Citation:
PMID:  11744638     Owner:  NLM     Status:  MEDLINE    
It is thought that changes in sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) of skeletal muscle contribute to alterations in skeletal muscle function during congestive heart failure (CHF). It is well established that exercise training can improve muscle function. However, it is unclear whether similar adaptations will result from exercise training in a CHF patient. Therefore, the purpose of this study was to determine whether skeletal muscle during moderate CHF adapts to increased activity, utilizing the functional overload (FO) model. Significant increases in plantaris mass of the CHF-FO and sham-FO groups compared with the CHF and control (sham) groups were observed. Ca(2+) uptake rates were significantly elevated in the CHF group compared with all other groups. No differences were detected in Ca(2+) uptake rates between the CHF-FO, sham, and sham-FO groups. Increases in Ca(2+) uptake rates in moderate-CHF rats were not due to changes in SERCA isoform proportions; however, FO may have attenuated the CHF-induced increases through alterations in SERCA isoform expression. Therefore, changes in skeletal muscle Ca(2+) handling during moderate CHF may be due to alterations in regulatory mechanisms, which exercise may override, by possibly altering SERCA isoform expression.
Espen E Spangenburg; Simon J Lees; Jeff S Otis; Timothy I Musch; Robert J Talmadge; Jay H Williams
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  92     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2001-12-17     Completed Date:  2002-04-10     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  18-24     Citation Subset:  IM; S    
Muscular Function Laboratory, Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
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MeSH Terms
Blotting, Western
Calcium / metabolism
Calcium-Transporting ATPases / biosynthesis
Heart Failure / metabolism,  physiopathology*
Heart Ventricles / pathology
Muscle, Skeletal / metabolism,  physiology*
Myocardial Infarction / pathology,  physiopathology
Myocardium / pathology
Organ Size / physiology
Rats, Sprague-Dawley
Sarcoplasmic Reticulum / metabolism,  physiology
Sarcoplasmic Reticulum Calcium-Transporting ATPases
Grant Support
Reg. No./Substance:
7440-70-2/Calcium; EC ATPases; EC Reticulum Calcium-Transporting ATPases
E E Spangenburg / VA Polytech & St U, Blacksburg

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