| Effects of moderate heart failure and functional overload on rat plantaris muscle. | |
| | |
MedLine Citation:
|
PMID: 11744638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It is thought that changes in sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) of skeletal muscle contribute to alterations in skeletal muscle function during congestive heart failure (CHF). It is well established that exercise training can improve muscle function. However, it is unclear whether similar adaptations will result from exercise training in a CHF patient. Therefore, the purpose of this study was to determine whether skeletal muscle during moderate CHF adapts to increased activity, utilizing the functional overload (FO) model. Significant increases in plantaris mass of the CHF-FO and sham-FO groups compared with the CHF and control (sham) groups were observed. Ca(2+) uptake rates were significantly elevated in the CHF group compared with all other groups. No differences were detected in Ca(2+) uptake rates between the CHF-FO, sham, and sham-FO groups. Increases in Ca(2+) uptake rates in moderate-CHF rats were not due to changes in SERCA isoform proportions; however, FO may have attenuated the CHF-induced increases through alterations in SERCA isoform expression. Therefore, changes in skeletal muscle Ca(2+) handling during moderate CHF may be due to alterations in regulatory mechanisms, which exercise may override, by possibly altering SERCA isoform expression. |
| | |
Authors:
|
Espen E Spangenburg; Simon J Lees; Jeff S Otis; Timothy I Musch; Robert J Talmadge; Jay H Williams |
Related Documents
:
|
8957598 - Cardiopulmonary determinants of functional capacity in patients with chronic heart fail... 20874858 - Preserved metabolic reserve capacity in skeletal muscle of post-infarction heart failur... 8007798 - Exercise testing and training in patients with chronic heart failure. 17000558 - External dose rates in radioiodine treatment of benign goitre: estimation versus direct... 7015818 - Toward the optimal lead system and optimal criteria for exercise electrocardiography. 6706758 - Ventilatory muscles during exercise in air and oxygen in normal men. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 92 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2002 Jan |
Date Detail:
|
Created Date: 2001-12-17 Completed Date: 2002-04-10 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: 18-24 Citation Subset: IM; S |
Affiliation:
|
Muscular Function Laboratory, Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA. spangenburge@missouri.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blotting, Western Calcium / metabolism Calcium-Transporting ATPases / biosynthesis Female Heart Failure / metabolism, physiopathology* Heart Ventricles / pathology Muscle, Skeletal / metabolism, physiology* Myocardial Infarction / pathology, physiopathology Myocardium / pathology Organ Size / physiology Rats Rats, Sprague-Dawley Sarcoplasmic Reticulum / metabolism, physiology Sarcoplasmic Reticulum Calcium-Transporting ATPases |
| Grant Support | |
ID/Acronym/Agency:
|
AR-41727/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
7440-70-2/Calcium; EC 3.6.1.8/Calcium-Transporting ATPases; EC 3.6.3.8/Sarcoplasmic Reticulum Calcium-Transporting ATPases |
| Investigator | |
Investigator/Affiliation:
|
E E Spangenburg / VA Polytech & St U, Blacksburg |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Blood pressure and mesenteric resistance arterial function after spaceflight.
Next Document: Dopaminergic modulation of ventilation in obese Zucker rats.