Document Detail

Effects of moderate exercise on cigarette smoke exposure-induced hippocampal oxidative stress values and neurological behaviors in mice.
MedLine Citation:
PMID:  20303389     Owner:  NLM     Status:  MEDLINE    
The objective of the present study was to investigate the effects of exercise training on behavior and neurochemical parameters in mice exposed to cigarette smoke. To this aim, mice (C57 BL6) male (30-35 g) were exposed to cigarette smoke 60 consecutive days three times a day and they were subjected to treadmill training 8 weeks for 5 days/week. For behavior assessment, mice were tested in the open-field and forced to a swim test. The superoxide anion, thiobarbituric acid reactive substances and protein carbonyl formation were measured as markers of oxidative stress in hippocampus of mice. In addition, the brain-derived neurotrophic factor (BDNF) levels were measured in the hippocampus samples. Cigarette smoke group and cigarette smoke plus exercise group, increased immobility time in forced swimming test in rats compared to the control group, without affecting spontaneous locomotor activity. There was an increase in the levels of superoxide, TBARS and of protein carbonyl and a decreased in BDNF levels in the hippocampus of rats exposed to cigarette smoke and cigarette smoke plus exercise. Exercise alone did not change any of the parameters evaluated in this study. In conclusion, we observed that physical training improves the oxidative stress parameters, but does not alter depressive-like behavior neither prevent the decreases in BDNF levels in hippocampus induced by cigarette smoke.
Talita Tuon; Samira S Valvassori; J?ssica Lopes-Borges; Gabriel R Fries; Luciano A Silva; Flavio Kapczinski; Jo?o Quevedo; Ricardo A Pinho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-18
Journal Detail:
Title:  Neuroscience letters     Volume:  475     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-19     Completed Date:  2010-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  16-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Exercise Biochemistry and Physiology Laboratory, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Crici?ma, SC, Brazil.
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MeSH Terms
Behavior, Animal*
Brain-Derived Neurotrophic Factor / metabolism
Hippocampus / metabolism
Mice, Inbred C57BL
Motor Activity*
Oxidative Stress*
Physical Conditioning, Animal*
Protein Carbonylation
Smoking / metabolism*,  psychology
Superoxides / metabolism
Thiobarbituric Acid Reactive Substances / metabolism
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 0/Thiobarbituric Acid Reactive Substances; 11062-77-4/Superoxides

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