Document Detail


Effects of mixed micellar lipids on carotenoid uptake by human intestinal caco-2 cells.
MedLine Citation:
PMID:  22738952     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We reported previously that lysophosphatidylcholine remarkably enhanced β-carotene uptake from bile acid-mixed micelles by human intestinal Caco-2 cells. In the present study, we evaluated how mixed micelle components other than phospholipids, viz., fatty acids, monoolein, and cholesterol, affect carotenoid uptake by Caco-2 cells. Each component influenced the β-carotene uptake in a different way depending on micellar composition. Oleic acid at 200 µM significantly enhanced uptake in the absence of lysophosphatidylcholine. Cholesterol at 40 µM significantly reduced uptake in the presence of lysophosphatidylcholine, while no reduction was found in the presence of 200 µM oleic acid. Facilitated diffusion was suggested partly to mediate uptake in mixed micelles, except for mixed micelles containing 200 µM oleic acid. Uptake mediated by facilitated diffusion was approximately 20% of total uptake. Mixed micellar lipids have the potential to modify intestinal uptake.
Authors:
Eiichi Kotake-Nara; Akihiko Nagao
Publication Detail:
Type:  Journal Article     Date:  2012-05-07
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  76     ISSN:  1347-6947     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-06-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  875-82     Citation Subset:  IM    
Affiliation:
National Food Research Institute, National Agriculture and Food Research Organization.
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